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New Opportunity of Mycotoxin Elimination

机译:消除霉菌毒素的新机会

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It is generally agreed that farm animals should be protected against the adverse effects of mycotoxins.Of the available opportunities,recently the use of microorganisms for biotransformation of mycotoxins has been mcreasing.Detoxa Plus has been specially developed for enzymatic decomposition of mycotoxins in animal feeds via its active germ component.The present paper summarise the main findings of three experiments that either had been published *** (Kutasi,J.,Papp Z.,Jakab.L.,Brydl,E.,Rafai P.: Deactivation of T-2 toxin in broiler ducks by biotransformation.J.Appl.Poult.Res..2012.21.13-20.),being published * * (Rafai P.,Papp Z.,Jakab 1.: Biotransformation of trichothecenes alleviates the negative effects of T-2 toxin in pigs.Acta Vet.Hung.AVH 116/2012)or submitted for publication * (Bata (A),Vanyi A.,Glávits,R.,Brydl E.,Rafai P.: Alleviation of the oestrogenic effect of zearalenone in pigs by a feed additive.Acta Vet.Brno,2013).Our experiments with growing pigs demonstrated that T-2 toxin impairs feed intake and weight gain of growing pigs at as low as 0.3 and 0.5 mg/kg feed concentration.The feed additive used in the present experiment improved the feed intake and daily weight gain of pig significantly.Although parameters of improved feed consumption and weight gain numerically lagged behind those of the control pigs the gap between data of experimentally treated pigs and controls was small and statistically not significant.Another experiment provided data on the preventive capacity of Detoxa Plus against oestrogen mimetic Zearalenone.The positive effects included the prevention of ovarian and uterine enlargement,beneficial effects on the histopathological scores of the ovaries.uterus and vagina and reduced concentration of Zea and its metabolites in the liver.In experiments with broiler ducks the adverse effect of 0.6 ppm dietary T-2 toxin was fully counteracted by the feed additive in terms of daily weight gain,cumulative daily weight gain and live weight at exsanguinations.T-2 toxin depressed the blastogenic response of lymphocytes to non-specific mitogens (ConA and PHA)which was fully prevented by the feed additive.
机译:人们普遍认为应该保护牲畜免受霉菌毒素的不利影响。在可获得的机会中,最近越来越多地使用微生物进行霉菌毒素的生物转化。DetoxaPlus是专门为酶解动物饲料中霉菌毒素而开发的。本文总结了三个已发表的实验的主要发现***(Kutasi,J.,Papp Z.,Jakab.L。,Brydl,E.,Rafai P .:通过生物转化在肉鸭中产生-2毒素.J.Appl.Poult.Res..2012.21.13-20。),已发表* *(Rafai P.,Papp Z.,Jakab 1:天花粉蛋白的生物转化减轻了负面影响猪中T-2毒素的含量.Acta Vet.Hung.AVH 116/2012)或已提交发表*(Bata(A),Vanyi A.,Glávits,R.,Brydl E.,Rafai P .:缓解雌激素饲料添加剂对玉米赤霉烯酮的影响(Acta Vet.Brno,2013)。我们对生长中的猪进行的实验表明T-2在0.3和0.5 mg / kg的饲料浓度下,毒素会损害生长猪的采食和增重。本实验中使用的饲料添加剂显着改善了猪的采食量和日增重。体重增加在数值上落后于对照组猪,实验处理的猪与对照组的数据之间的差距很小并且在统计学上不显着。另一项实验提供了Detoxa Plus对雌激素模拟玉米赤霉烯酮的预防能力数据,积极的影响包括预防卵巢和子宫增大,对卵巢,子宫和阴道的组织病理学评分有益,并降低了玉米中Zea及其代谢产物的浓度。在肉鸭实验中,0.6 ppm的饮食中T-2毒素的不良反应可完全抵消饲料添加剂的日增重,累计日增重和活体重T-2毒素抑制了淋巴细胞对非特异性促细胞分裂剂(ConA和PHA)的成胚反应,饲料添加剂可以完全阻止这种作用。

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