Investigation of image-guided sonothrombolysis in a porcine acute ischemic stroke model

机译：猪急性缺血性脑卒中模型中图像引导的超声溶栓治疗的研究

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Image-guided sonothrombolysis was prototyped on a modified ultrasound imaging system iE33 and further evaluated using a porcine acute ischemic stroke model. After 20 to 40 minute sonothrombolysis treatment with systemic infusion of Definity microbubbles, contrast reperfusion and arterial recanalization were observed on low MI ultrasound contrast imaging and X-ray based angiography, respectively. The study indicates that a modified diagnostic imaging system can be utilized with systemic microbubble infusion to rapidly restore cerebral blood flow in acute ischemic stroke.

机译：在改进的超声成像系统iE33上原型化了图像引导的超声溶栓治疗，并使用猪急性缺血性卒中模型进行了进一步评估。在全身灌注Definity微泡的声波溶栓治疗20至40分钟后，分别在低MI超声造影成像和基于X射线的血管造影术上观察到造影剂再灌注和动脉再通。研究表明，改良的诊断成像系统可与全身微泡输注一起使用，以快速恢复急性缺血性中风的脑血流。

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《2011 IEEE International Ultrasonics Symposium》|2011年|p.5- 8|共4页
会议地点 Orlando FL(US)
作者
Shi William T.; Porter Thomas R.; Vignon Francois; Powers Jeffry E.; Gao Shunji; Liu Jinjin; Xie Feng; Drvol Lucas; Lof John; Everbach E. Carr;
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Philips Research North America, 345 Scarborough Road, Briarcliff Manor, NY 10510, USA;

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原文格式 PDF
正文语种 eng
中图分类超声工程;
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1. In?vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model [J] . Yuming Teng, Haiqiang Jin, Ding Nan, Bioactive Materials . 2018,第1期

机译：负载尿激酶的空心纳米凝胶在体内的血栓溶解诱导的缝线栓塞诱发的急性缺血性中风大鼠模型的体内评价
2. Microbubble-augmented ultrasound sonothrombolysis decreases intracranial hemorrhage in a rabbit model of acute ischemic stroke. [J] . Flores R, Hennings LJ, Lowery JD, Investigative radiology . 2011,第7期

机译：在急性缺血性中风的兔子模型中，微泡增强超声超声溶栓治疗可减少颅内出血。
3. Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke. [J] . Culp WC, Flores R, Brown AT, Stroke: A Journal of Cerebral Circulation . 2011,第8期

机译：没有组织型纤溶酶原激活剂的成功的微泡声纳溶栓治疗兔急性缺血性中风。
4. Investigation of image-guided sonothrombolysis in a porcine acute ischemic stroke model [C] . Shi William T., Porter Thomas R., Vignon Francois, IEEE Ultrasonics Symposium . 2011

机译：猪急性缺血性卒中模型中的图像引导孤腐族栓塞的研究
5. Nutritional intervention and modeling of acute ischemic stroke . [D] . Rink, Cameron. 2008

机译：急性缺血性脑卒中的营养干预和建模。
6. In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model [O] . Yuming Teng, Haiqiang Jin, Ding Nan, 2018

机译：负载尿激酶的中空纳米凝胶在缝合栓塞诱发的急性缺血性中风大鼠模型中的溶栓作用的体内评估
7. NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study): Randomized controlled contrast-enhanced sonothrombolysis in an unselected acute ischemic stroke population [O] . Nacu, Aliona, Kvistad, Christopher Elnan, Næss, Halvor, 2016

机译：NOR-sass（急性卒中研究中的挪威超声波溶栓）：未经选择的急性缺血性卒中人群的随机对照增强血液溶栓治疗

Investigation of image-guided sonothrombolysis in a porcine acute ischemic stroke model

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