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首页> 外文期刊>Stroke: A Journal of Cerebral Circulation >Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke.
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Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke.

机译：没有组织型纤溶酶原激活剂的成功的微泡声纳溶栓治疗兔急性缺血性中风。

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BACKGROUND AND PURPOSE: Microbubbles (MB) combined with ultrasound (US) have been shown to lyse clots without tissue-type plasminogen activator (tPA) both in vitro and in vivo. We evaluated sonothrombolysis with 3 types of MB using a rabbit embolic stroke model. METHODS: New Zealand White rabbits (n=74) received internal carotid angiographic embolization of single 3-day-old cylindrical clots (0.6x4.0 mm). Groups included: (1) control (n=11) embolized without treatment; (2) tPA (n=20); (3) tPA+US (n=10); (4) perflutren lipid MB+US (n=16); (5) albumin 3 mum MB+US (n=8); and (6) tagged albumin 3 mum MB+US (n=9). Treatment began 1 hour postembolization. Ultrasound was pulsed-wave (1 MHz; 0.8 W/cm(2)) for 1 hour; rabbits with tPA received intravenous tPA (0.9 mg/kg) over 1 hour. Lipid MB dose was intravenous (0.16 mg/kg) over 30 minutes. Dosage of 3 mum MB was 5x10(9) MB intravenously alone or tagged with eptifibatide and fibrin antibody over 30 minutes. Rabbits were euthanized at 24 hours. Infarct volume was determined using vital stains on brain sections. Hemorrhage was evaluated on hematoxylin and eosin sections. RESULTS: Infarct volume percent was lower for rabbits treated with lipid MB+US (1.0%+/-0.6%; P=0.013), 3 mum MB+US (0.7%+/-0.9%; P=0.018), and tagged 3 mum MB+US (0.8%+/-0.8%; P=0.019) compared with controls (3.5%+/-0.8%). The 3 MB types collectively had lower infarct volumes (P=0.0043) than controls. Infarct volume averaged 2.2%+/-0.6% and 1.7%+/-0.8% for rabbits treated with tPA alone and tPA+US, respectively (P=nonsignificant). CONCLUSIONS: Sonothrombolysis without tPA using these MB is effective in decreasing infarct volumes. Study of human application and further MB technique development are justified.
机译：背景和目的：已经证明，微泡（MB）与超声（US）结合可以在体外和体内裂解不含组织型纤溶酶原激活剂（tPA）的血块。我们使用兔栓塞性卒中模型评估了3种类型的MB的声音溶栓。方法：新西兰白兔（n = 74）接受了3天大的单个圆柱形血栓（0.6x4.0 mm）的颈内动脉血管造影栓塞术。分组包括：（1）对照（n = 11）未经治疗栓塞; （2）tPA（n = 20）; （3）tPA + US（n = 10）; （4）全氟哌啶脂MB + US（n = 16）; （5）白蛋白3妈妈MB + US（n = 8）; （6）标记的白蛋白3兆MB + US（n = 9）。栓塞后1小时开始治疗。超声脉冲波（1 MHz; 0.8 W / cm（2））1小时;患有tPA的兔子在1小时内接受了静脉tPA（0.9 mg / kg）。在30分钟内静脉注射脂质MB剂量（0.16 mg / kg）。 3兆MB的剂量是单独静脉注射5x10（9）MB，或在30分钟内用eptifibatide和血纤蛋白抗体标记。在24小时对安乐死的兔子进行安乐死。使用脑部切片上的活菌染色确定梗死体积。在苏木和曙红切片上评估出血情况。结果：用脂质MB + US（1.0％+ /-0.6％; P = 0.013），3妈妈MB + US（0.7％+ /-0.9％; P = 0.018）治疗并加标签的兔梗死体积百分比更低与对照组（3.5％+ /-0.8％）相比，3兆MB + US（0.8％+ /-0.8％; P = 0.019）。与对照相比，3 MB类型的梗塞体积较小（P = 0.0043）。单独用tPA和tPA + US治疗的兔子的梗塞体积平均分别为2.2％+ /-0.6％和1.7％+ /-0.8％（P =无统计学意义）。结论：使用这些MB的无tPA的溶栓治疗可有效减少梗死体积。对人类应用的研究以及MB技术的进一步发展是合理的。

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