A two-compartment fractional derivative model for Propofol diffusion in anesthesia

机译：麻醉中异丙酚扩散的两室分数导数模型

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This paper presents the initial steps towards the development of a compartmental model for Propofol diffusion in the human body using concepts from fractional calculus. The model presented here preserves the mass balance, therefore it maintains the link between physiological and mathematical parameters. The final purpose of this model is to predict drug pharmacokinetics and pharmacodynamics during general anesthesia. A comparison of the proposed a fractional order model and the integer order compartmental model of Propofol shows good agreement between them.

机译：本文介绍了使用分数演算的概念开发异丙酚在人体内扩散的隔室模型的初步步骤。这里介绍的模型可以保持质量平衡，因此可以保持生理参数和数学参数之间的联系。该模型的最终目的是预测全身麻醉期间的药物药代动力学和药效学。所提议的丙泊酚分数阶模型和整数阶间隔模型的比较表明它们之间有很好的一致性。

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来源
《2013 IEEE International Conference on Control Applications》|2013年|264-269|共6页
会议地点 Hyderabad(IN)
作者
Copot Dana; Chevalier Amelie; Ionescu Clara M.; De Keyser Robin;
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作者单位

Department of Electrical Energy, Systems and Automation, Ghent University, Technologiepark 913, 9052 Gent, Belgiumc;

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原文格式 PDF
正文语种 eng
中图分类
关键词
Anesthesia; Compartmental model; Diffusion; Fractional calculus;

机译：麻醉;隔室模型;扩散;碎屑演算;;

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A two-compartment fractional derivative model for Propofol diffusion in anesthesia

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