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首页> 外文会议>2013 IEEE Nuclear Science Symposium and Medical Imaging Conference >Performance evaluation of interpolated average CT for PET attenuation correction in different lesion characteristics
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Performance evaluation of interpolated average CT for PET attenuation correction in different lesion characteristics

机译：插值平均CT在不同病变特征下PET衰减校正的性能评估

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Previously we demonstrated the effectiveness of the interpolated average CT (IACT) for attenuation correction (AC) in PET in simulations and clinical patients. This study aims to evaluate the performance of IACT for thoracic lesions with different sizes, uptake ratios and locations. The XCAT phantom was used to simulate noisy 18F-FDG distribution based on the clinical count level with respiratory motion amplitude of 2 cm and 3 cm. The average activity and attenuation maps represented static PET and cine average (CACT) respectively. IACT was generated by the end-inspiration and end-expiration phases of the attenuation maps (HCT-in and HCT-ex) using deformable registration method. Spherical 10 mm and 20 mm lesions were simulated at 4 locations individually, including the lower left lung (LLL), lower right lung (LRL), middle right lung (MRL) and upper right lung (URL). Four target-to-background ratios (TBR), including 4∶1 and 8∶1 for respiratory motion of 2 cm, 6∶1 and 12∶1 for respiratory motion of 3 cm, were modeled. The noisy sinograms with attenuation modeling were generated and reconstructed with different AC maps by STIR (Software for Tomographic Image Reconstruction), using OS-EM with up to 300 updates. Normalized mean square error (NMSE), mutual information (MI) and TBR were analyzed. The NMSE and MI results showed that PETCACT and PETIACT were more similar to the original phantom as compared to PETHCTs. For TBRs, the differences between CACT/IACT and HCTs AC were more significant for lesions in the lower lung with PETHCT-ex showed higher TBR and PETHCT-in showed lower TBR as compared to PETCACT/PETIACT for all lesion sizes, uptake ratios and respiratory motion amplitudes. The TBRs for 10 mm lesion were more difficult to be recovered in all AC schemes. Better lesion localization and more stable quantitation for different lesion characteristic- make IACT a good alternate for AC as compared to conventional HCT/CACT.
机译：先前，我们在模拟和临床患者中证明了插值平均CT（IACT）对PET中的衰减校正（AC）的有效性。这项研究旨在评估IACT对不同大小，摄取率和位置的胸腔病变的表现。基于临床计数水平，呼吸运动幅度分别为2 cm和3 cm，使用XCAT幻像模拟有噪声的 18 F-FDG分布。平均活性图和衰减图分别代表静态PET和电影平均值（CACT）。 IACT是通过使用可变形配准方法在衰减图（HCT-in和HCT-ex）的吸气末期和呼气末期阶段生成的。分别在4个位置模拟了球形10 mm和20 mm病变，包括左下肺（LLL），右下肺（LRL），右中肺（MRL）和右上肺（URL）。建模了四个目标背景比（TBR），包括2 cm呼吸运动的41：1和81：1、3 cm呼吸运动的61：1和121：1。使用OS-EM并进行多达300次更新，使用STIR（断层图像重建软件）生成了带有衰减模型的嘈杂正弦图，并使用不同的AC图进行了重建。分析归一化均方误差（NMSE），互信息（MI）和TBR。 NMSE和MI结果表明，与PETHCT相比，PETCACT和PETIACT与原始体模更相似。对于TBR，与PETCACT / PETIACT相比，在所有病变大小，摄取率和呼吸方面，PETHCT-ex显示较高的TBR和PETHCT-in显示较低的TBR，CACT / IACT与HCTs AC在下肺病变中的差异更为显着运动幅度。在所有AC方案中，10 mm病变的TBR均较难恢复。与传统的HCT / CACT相比，更好的病灶定位和针对不同病灶特征的更稳定的定量分析-使IACT成为AC的良好替代方案。

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