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首页> 外文会议>2014 40th Annual Northeast Bioengineering Conference >Functional connectivity of vergence neural substrates
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Functional connectivity of vergence neural substrates

机译：收敛神经底物的功能连接

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While fMRI has identified which regions of interests (ROI) are functionally active during a vergence task (the inward or outward rotation of eyes), the functional connectivity between ROIs is less understood. This study tested the following hypotheses: 1) significant functional connectivity would be observed between the frontal eye fields (FEF), the posterior parietal cortex (PPC) and the cerebellar vermis (CV), 2) significantly more functional activity and connectivity would be observed in binocularly normal controls (BNC) compared to patients with convergence insufficiency (CI), and 3) after vergence training, the functional activity and connectivity would improve in CI subjects compared to their baseline measurements. A block design of sustained fixation versus vergence eye movements stimulated activity in the FEF, PPC and CV. FMRI data from four CI subjects before and after vergence training were compared to seven BNC. Functional activity was assessed using the BOLD percent signal change. Functional connectivity was assessed using a seed-based functional connectivity analysis, which revealed significant correlation between the FEF, PPC and CV ROIs.
机译：尽管功能磁共振成像（MRI）已确定在散瞳任务（眼睛向内或向外旋转）过程中感兴趣的区域（ROI）在功能上处于活动状态，但对ROI之间的功能连接性了解较少。这项研究检验了以下假设：1）在额叶视野（FEF），顶叶后皮质（PPC）和小脑ver（CV）之间将观察到显着的功能连通性，2）在观察到的功能活动和连通性上将显着提高在双眼正常对照（BNC）中与有收敛性供血不足（CI）的患者进行比较，以及3）在进行视力训练后，与受试者的基线测量值相比，CI受试者的功能活动和连接性将得到改善。持续固定与发散眼球运动的方框设计可刺激FEF，PPC和CV中的活动。将来自四名CI受试者在融合训练前后的FMRI数据与七个BNC进行比较。使用BOLD百分比信号变化来评估功能活性。使用基于种子的功能连接性分析评估功能连接性，该分析揭示了FEF，PPC和CV ROI之间的显着相关性。

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