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首页> 外文会议>2014 40th Annual Northeast Bioengineering Conference >Biomimetic fabrication and freeze-casting of collagen-apatite hydrogels for bone tissue engineering
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Biomimetic fabrication and freeze-casting of collagen-apatite hydrogels for bone tissue engineering

机译：用于骨组织工程的仿生制造和胶原磷灰石水凝胶的冻铸

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摘要

Collagen-apatite (Col-Ap) scaffolds have been widely employed for bone tissue engineering. In the current study, we fabricated Col-Ap hydrogels with a biomimetic structure and freeze-dried Col-Ap hydrogels with a hierarchical lamellar structure. Col-Ap hydrogel was prepared using a biomimetic approach combining self-assembling of collagen molecules with simultaneous mineralization in a modified simulated body fluid (m-SBF). A novel two-temperature process involving gelation at 25 C and then 40 C was applied to increase the diameter of mineralized collagen fibers. Col-Ap hydrogel consisting of collagen bundles reinforced by apatite nano-particles was further subjected to self-compression and controlled freeze-casting. The freeze-dried hydrogel exhibits a hierarchical lamellar structure consisting of co-aligned macro and micro pores. Moreover, this novel lamellar structured scaffold supports the attachment and spreading of MC3T3-E1osteoblasts. Therefore, owing to the biomimetic composition, hierarchical lamellar structure and good biocompatibility of this novel freeze-dried Col-Ap hydrogel, it has great potential to be used in bone tissue engineering applications.
机译：胶原磷灰石（Col-Ap）支架已被广泛用于骨组织工程。在当前的研究中，我们制造了具有仿生结构的Col-Ap水凝胶和具有分层层状结构的冻干的Col-Ap水凝胶。使用仿生方法将胶原分子的自组装与在改良的模拟体液（m-SBF）中同时矿化相结合来制备Col-Ap水凝胶。涉及在25°C然后40°C凝胶化的新型两温法，用于增加矿化的胶原纤维的直径。由由磷灰石纳米颗粒增强的胶原束组成的Col-Ap水凝胶进一步进行自压缩和受控的冷冻浇铸。冷冻干燥的水凝胶显示出由共同排列的大孔和微孔组成的分层层状结构。而且，这种新颖的层状结构支架支持MC3T3-E1成骨细胞的附着和扩散。因此，由于该新型冷冻干燥的Col-Ap水凝胶的仿生成分，分层的层状结构和良好的生物相容性，其在骨组织工程应用中具有很大的潜力。

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