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首页> 外文会议>2016 International Conference on Bioinformatics and Systems Biology >Identification of functional genetic variants in miRNA binding site in genes associated with lung cancer
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Identification of functional genetic variants in miRNA binding site in genes associated with lung cancer

机译：肺癌相关基因miRNA结合位点功能性遗传变异的鉴定

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摘要

The miRNAs are 22-46 nucleotidelong, non-protein coding RNAsthat act as oncogenes. Their altered expression can cause diseases, includingcancer. Lung cancer is causing death of million peopleworldwide. Yet only few genetic biomarkers are known for detecting lung cancer. miRNAs are those non-coding RNAs that act as such biomarkers. They act as oncogenes and regulate many biological processesand cellular pathways. The miRNAs regulate gene expression of protein coding genes by generating either translation repression or RNAdegradation. When they bind with 3' UTR of newly formed miRNA transcripts along with other helper proteins, they inhibit their expression and function. This translation inhibition, affects tumor suppressor genes and leads to cancer.miRNAexpression deregulation found in various cancers such as Prostrate, Breast, Colonialand Lung canceretc. In this study insilico approach has been used to find out functional genetic variation in miRNA binding sites of genes responsible for causing lung cancer. As a result of this study we have found 7 SNPs involved in such cancers-rs6772, rs1036672, rs739442, rs1050700, rs3185695, rs12723035, rs3787030. These SNPs can act as candidate biomarkers for lung cancer.
机译：miRNA是22-46个核苷酸长的非蛋白编码RNA，可作为癌基因。它们的表达改变会导致疾病，包括癌症。肺癌正在全球范围内造成数百万人死亡。然而，只有很少的遗传生物标志物可用于检测肺癌。 miRNA是充当此类生物标记的非编码RNA。它们充当癌基因并调节许多生物学过程和细胞途径。 miRNA通过产生翻译抑制或RNA降解来调节蛋白质编码基因的基因表达。当它们与新形成的miRNA转录物的3'UTR以及其他辅助蛋白结合时，它们会抑制其表达和功能。这种翻译抑制作用影响肿瘤抑制基因并导致癌症。miRNA表达失调存在于多种癌症中，例如Prostrate，Breast，Colonialand Lung癌症等。在这项研究中，insilico方法已用于找出导致肺癌的基因的miRNA结合位点的功能遗传变异。这项研究的结果是，我们发现了7种SNP参与了此类癌症-rs6772，rs1036672，rs739442，rs1050700，rs3185695，rs12723035，rs3787030。这些SNP可以充当肺癌的候选生物标记。

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