Identification of conserved regulatory motif signatures in human miRNA upstream regions

机译：鉴定人miRNA上游区域中保守的调控基序特征

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摘要

Discovering and characterizing regulatory elements of miRNA genes are fundamental problems in bioinformatics field. An upstream regulatory motif can be described as a sequence element designated for binding of various protein factors imparting their subsequent effects on the transcription of the genes. For example, the transcription factors often bind to cis-acting conserved motif to regulate transcription, which typically are located upstream of transcriptional start sites. This work focuses on the identification of upstream regulatory elements of human microRNA genes by screening of their Kullback Liebler distance.

机译：发现和表征miRNA基因的调控元件是生物信息学领域的基本问题。上游调节基序可以描述为指定用于结合各种蛋白质因子的序列元件，从而赋予它们随后的基因转录作用。例如，转录因子通常与顺式作用的保守基序结合以调节转录，所述转录通常位于转录起始位点的上游。这项工作的重点是通过筛选人类microRNA基因的Kullback Liebler距离来鉴定其上游调控元件。

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来源
《2016 International Conference on Bioinformatics and Systems Biology》|2016年|1-3|共3页
会议地点 Allahabad(IN)
作者
Pankaj Kumar Singh; Jayita Roy nee Ghoshal; Sayak Ganguli; Protip Basu; Vineet Vishal; Abhisek Ranjan Bera; Abhaydeep Pandey; Rahul Banik;
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作者单位

Dept. of Anthropology, Narasinha Dutt College, Howrah - 711101, West Bengal, India;

Dept. of Anthropology, Narasinha Dutt College, Howrah - 711101, West Bengal, India;

Theoretical and Computational Biology Division, Amplicon Biosciences (P) Ltd., Palta-743122, West Bengal, India;

Bioinformatics Division, The Biome, Kolkata-700064, West Bengal, India;

Bioinformatics Division, The Biome, Kolkata-700064, West Bengal, India;

Bioinformatics Division, The Biome, Kolkata-700064, West Bengal, India;

Bioinformatics Division, The Biome, Kolkata-700064, West Bengal, India;

Bioinformatics Division, The Biome, Kolkata-700064, West Bengal, India;

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原文格式 PDF
正文语种 eng
中图分类
关键词
RNA; Bioinformatics; Databases; Proteins; Gene expression; Encoding; Computational biology;

机译：RNA;生物信息学;数据库;蛋白质;基因表达;编码;计算生物学;

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专利

1. Identification of specific sequence motifs in the upstream region of 242 human miRNA genes [J] . Atsushi Inouchi, Shuichi Shinohara, Hiroshi Inoue, Computational biology and chemistry . 2007,第3期

机译：鉴定242个人类miRNA基因上游区域中的特定序列基序
2. Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA–TF–gene network approach in humans and mice [J] . Aimin Li, Peilin Jia, Saurav Mallik, Briefings in bioinformatics . 2020,第4期

机译：通过守恒的MiRNA-TF基因网络方法在人和小鼠中鉴定的腭裂中的临界小鼠和调节基序
3. Identification of putative regulatory motifs in the upstream regions of co-expressed functional groups of genes in Plasmodium falciparum [J] . Prathima Iengar, NV Joshi BMC Genomics . 2009,第1期

机译：恶性疟原虫共表达的功能基因组上游区域推定的调控基元的鉴定
4. Identification of conserved regulatory motif signatures in human miRNA upstream regions [C] . Pankaj Kumar Singh, Jayita Roy nee Ghoshal, Sayak Ganguli, International Conference on Bioinformatics and Systems Biology . 2016

机译：人体miRNA上游地区保守监管主题鉴定的识别
5. Identification of regulatory elements in a conserved upstream region of the gene encoding interphotoreceptor retinoid-binding protein (IRBP). [D] . Lu, Haiyan. 1998

机译：鉴定编码光受体间类视黄醇结合蛋白（IRBP）的基因的保守上游区域中的调节元件。
6. Identification of putative regulatory motifs in the upstream regions of co-expressed functional groups of genes in Plasmodium falciparum [O] . Prathima Iengar, NV Joshi 2009

机译：恶性疟原虫共表达功能基因组上游区域推定的调控基元的鉴定
7. Bioprospector: Discovering Conserved Dna Motifs In Upstream Regulatory Regions Of Co-Expressed Genes [O] . Liu Stanford Medical, X. Liu, D. L. Brutlag, 2001

机译：Bioprospector：在共表达基因的上游调控区发现保守的Dna基序

Identification of conserved regulatory motif signatures in human miRNA upstream regions

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