Pharmacodynamic model of neuroendocrine controlled blood pressure

机译：神经内分泌控制血压的药效学模型

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In this present work, the authors proposed a pharmacodynamic model which reflects the effects of both antihypertensive and the antidepressant agents on the signalling pathways associated with blood pressure concomitant with the action of neuroendocrine messengers. There are large numbers of signalling and metabolic pathways associated with blood pressure. The parameters associated with the neuroendocrine signaling pathways are altered in diseased state of a subject. Here the authors endeavoured to develop a model how the pharmacodynamic effects of antihypertensive or antidepressant agents change the dynamics of certain signalling pathways which affect the blood pressure.

机译：在这项目前的工作中，作者提出了一个药效学模型，该模型反映了降压药和抗抑郁药对与神经内分泌信使作用相关的血压相关信号通路的影响。与血压相关的信号传导和代谢途径很多。与神经内分泌信号传导途径相关的参数在受试者的患病状态中改变。在这里，作者努力开发一种模型，以说明抗高血压药或抗抑郁药的药效作用如何改变某些影响血压的信号通路的动态。

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来源
《2016 International Conference on Microelectronics, Computing and Communications》|2016年|1-6|共6页
会议地点 Durgapur(IN)
作者
Ashis Kumar Das; Suman Halder;
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作者单位

Electrical Engineering Dept., National Institute of Technology, Durgapur, India;

Electrical Engineering Dept., National Institute of Technology, Durgapur, India;

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会议组织
原文格式 PDF
正文语种 eng
中图分类
关键词
Proteins; Blood pressure; Calcium; Muscles; Antidepressants; Neurotransmitters;

机译：蛋白质;血压;钙;肌肉;抗抑郁药;神经递质;

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Pharmacodynamic model of neuroendocrine controlled blood pressure

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