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首页> 外文会议>2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems amp; Eurosensors XXXIII >High-Throughput Interdigitated Electrode Array on Microgroove-Patterned Cantilever to Measure Electro-Mechanical Properties of Cardiomyocytes
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High-Throughput Interdigitated Electrode Array on Microgroove-Patterned Cantilever to Measure Electro-Mechanical Properties of Cardiomyocytes

机译：微通量模式悬臂上的高通量指状电极阵列，用于测量心肌细胞的机电性能

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摘要

This study reports a new MEMS-based cantilever device that simultaneously measures the mechanical force and electrophysiology of cardiac cells. On an interdigitated electrode (IDE) integrated with the cantilever, microgroove patterns are formed that positively influence the maturation and alignment of cardiac cells. The fabricated cantilever device can directly measure impedance of the cardiac cells as well as the displacement that occurs because of the contractions of cardiac cells. After the preliminary experiments, the cardiac cells were subjected to Verapamil drug in order to measure the drug-induced cardiac toxicity. Displacement of the cantilever in presence of Verapamil was lower than that in its absence, as were the impedance recordings.
机译：这项研究报告了一种新的基于MEMS的悬臂装置，该装置可以同时测量心脏细胞的机械力和电生理。在与悬臂集成的叉指式电极（IDE）上，形成了微沟槽图案，这些图案积极地影响了心肌细胞的成熟和排列。所制造的悬臂装置可以直接测量心脏细胞的阻抗以及由于心脏细胞的收缩而发生的位移。在初步实验后，对心肌细胞进行维拉帕米药物治疗，以测量药物诱导的心脏毒性。维拉帕米存在时的悬臂位移比不存在维拉帕米时的悬臂位移要低，阻抗记录也是如此。

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