首页> 外文会议>2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems amp; Eurosensors XXXIII >MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability
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MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability

机译:MEMS硅片切割器,用于快速限制扩散胰岛的切片,以提高生存能力

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This paper reports on the first MEMS silicon cutters designed to rapidly section donor pancreatic islets below oxygen diffusion-limited dimensions to improve viability of grafts during the critical period of re-implantation and revascularization by the host. The monolithic silicon chips feature an array of spaced nano-sharp (r < 100 nm) blades that cleanly section islet tissue. This work represents the first time that sectioning of pancreatic islets has been proposed and validated as a means to overcome the well-known problems of hypoxia and core-necrosis that is encountered in current islet transplantation procedures.
机译:本文报道了第一批MEMS硅切割器,该切割器旨在将供体胰岛快速切成低于氧扩散限制的尺寸,以在宿主重新植入和血运重建的关键时期提高移植物的生存能力。单片硅芯片具有一系列间隔清晰的纳米锐利(r <100 nm)刀片,可干净地切片胰岛组织。这项工作是首次提出并验证了胰岛的切片方法,以克服目前胰岛移植手术中遇到的缺氧和核心坏死的已知问题。

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