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Can passive mobilization provide clinically-relevant brain stimulation? A pilot eeg and nirs study on healthy subjects

机译:被动动员可以提供与临床相关的脑刺激吗?关于健康受试者的脑电图和神经网络试验研究

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Lower limb rehabilitation is a fundamental part of post-acute care in neurological disease. Early commencement of active workout is often prevented by paresis, thus physical treatment may be delayed until patients regain some voluntary command of their muscles. Passive mobilization of the affected joints is mostly delivered in order to safeguard tissue properties and shun circulatory problems. The present paper investigates the potential role of early passive motion in stimulating cortical areas of the brain devoted to the control of the lower limb. An electro-mechanical mobilizer for the ankle joint (Toe-Up!) was implemented utilizing specially-designed shape-memory-alloy-based actuators. This device was constructed to be usable by bedridden subjects. Besides, the slowness and gentleness of the imparted motion, make it suitable for patients in a very early stage of their recovery. The mobilizer underwent technical checks to confirm reliability and passed the required safety tests for electric biomedical devices. Four healthy volunteers took part in the pre-clinical phase of the study. The protocol consisted in measuring of brain activity by EEG and NIRS in four different conditions: rest, active dorsiflexion of the ankle, passive mobilization of the ankle, and assisted motion of the same joint. The acquired data were processed to obtain maps of cortical activation, which were then compared. The measurements collected so far show that there is a similar pattern of activity between active and passive/assisted particularly in the contralateral premotor areas. This result, albeit based on very few observations, might suggest that passive motion provides somatosensory afferences that are processed in a similar manner as for voluntary control. Should this evidence be confirmed by further trials on healthy individuals and neurological patients, it could form a basis for a clinical use of early passive exercise in supporting central functional recovery.
机译:下肢康复是神经疾病急性后护理的基本组成部分。经常由于麻痹而不能及早开始主动锻炼,因此物理治疗可能会延迟,直到患者重新获得对肌肉的自愿控制。被动移动受影响的关节主要是为了保护组织特性和避免循环问题。本文研究了早期被动运动在刺激致力于控制下肢的大脑皮质区域中的潜在作用。利用专门设计的基于形状记忆合金的执行器,实现了用于踝关节的电动机械动臂(Toe-Up!)。该设备被构造为可供卧床不起的受试者使用。此外,所传递的动作缓慢而柔和,使其非常适合处于康复初期的患者。动员者经过技术检查以确认可靠性,并通过了电动生物医学设备的必要安全测试。四名健康志愿者参加了该研究的临床前阶段。该协议包括在四种不同条件下通过EEG和NIRS测量大脑活动:休息,踝关节的主动背屈,踝关节的被动动员以及同一关节的辅助运动。处理获取的数据以获取皮层激活图,然后进行比较。迄今为止收集的测量结果表明,在主动和被动/辅助之间存在相似的活动模式,尤其是在对侧运动前区域。尽管基于很少的观察结果,该结果可能表明被动运动提供了体感障碍,其处理方式与自愿控制类似。如果通过对健康个体和神经系统患者的进一步试验证实了这一证据,则可以为早期被动锻炼在临床上支持中心功能恢复提供依据。

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