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首页> 外文会议>3rd frontiers in biomedical devices conference 2008 : Imaging and anatomic interaction ; Simulation and testing ; Device testing ... >Polymer-Based Sensors for Dynamic Intravascular Shear Stress Analysis
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Polymer-Based Sensors for Dynamic Intravascular Shear Stress Analysis

机译：用于动态血管内剪切应力分析的基于聚合物的传感器

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摘要

This paper describes a polymer-based shear stress sensor built on catheter for in vivo measurements and potential application in atherosclerosis diagnosis. MEMS shear stress sensor with backside wire bonding has been used to address in vitro applications for micro-scale hemodynamics with high temporal and spatial resolution. However, to assess shear stress in the tortuous and dynamic arterial circulation, we had to develop a new generation of polymer- and catheter-based sensors that are both flexible and deployable. The individual sensor was packaged near the tip of a catheter for intravascular shear stress analysis. The wire bonding and electrode leads were insulated by a film of Parylene C and were connected to the external circuit along the guide-wire. The sensor was deployed through the catheter into the aorta of New Zealand White (NZW) rabbits by the femoral cut-down procedure. Based on the heat transfer principle, the device was able to detect small temperature perturbation in response to the pulsatile flow at ～200 beats/minutes in the rabbits. The sensor was calibrated in the presence of rabbit blood flow at 37.8℃. We demonstrated the feasibility of translating a polymer-based device for dynamic intravascular measurement with a potential for clinical applications in detecting coronary artery disease and stroke.
机译：本文介绍了一种基于聚合物的剪切应力传感器，该传感器建立在导管上，用于体内测量和在动脉粥样硬化诊断中的潜在应用。具有背面引线键合的MEMS剪切应力传感器已用于解决具有高时空分辨率的微型血液动力学的体外应用。但是，为了评估弯曲和动态动脉循环中的剪切应力，我们不得不开发新一代的基于聚合物和导管的传感器，它们既灵活又可展开。单个传感器包装在导管尖端附近，用于血管内切应力分析。引线键合和电极引线由聚对二甲苯C膜绝缘，并沿导线连接到外部电路。通过股骨切开程序将传感器通过导管部署到新西兰白（NZW）兔的主动脉中。根据传热原理，该装置能够响应兔子在〜200次/分钟的搏动流而检测到较小的温度扰动。在兔血流量为37.8℃时对传感器进行校准。我们证明了转换基于聚合物的设备进行动态血管内测量的可行性，具有在临床应用中检测冠状动脉疾病和中风的潜力。

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  • 会议地点 Irvine CA(US);Irvine CA(US)
  • 作者

    Lisong Ai; Hongyu Yu; Mahsa Rouhanizadeh; Wakako Takabe; Ellis Meng; E.S. Kim; Tzung Hsiai;

  • 作者单位

    Departments of Biomedical Engineering and Cardiovascular Medicine USC Viterbi School of Engineering University of Southern California,Los Angeles, California 90089, USA;

    Departments of Biomedical Engineering and Cardiovascular Medicine USC Viterbi School of Engineering University of Southern California,Los Angeles, California 90089, USA;

    Departments of Biomedical Engineering and Cardiovascular Medicine USC Viterbi School of Engineering University of Southern California,Los Angeles, California 90089, USA;

    Departments of Biomedical Engineering and Cardiovascular Medicine USC Viterbi School of Engineering University of Southern California,Los Angeles, California 90089, USA;

    Departments of Biomedical Engineering and Cardiovascular Medicine USC Viterbi School of Engineering University of Southern C;

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