Environmental Epigenetics-Investigating the Environmental Programming of Human Disease

机译：环境表观遗传学-研究人类疾病的环境规划

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Epigenetics investigates heritable changes in gene expression that occur without changes in DNA sequence.Several epigenetic mechanisms,including DNA methylation and histone modifications,can change genome function under exogenous influence.Results obtained from animal models indicate that in utero or early-life environmental exposures produce effects that can be inherited transgenerationally and are accompanied by epigenetic alterations.The search for human equivalents of the epigenetic mechanisms identified in animal models is in progress.

机译：表观遗传学研究基因表达的可遗传变化，这些变化发生在DNA序列不变的情况下。几种表观遗传机制（包括DNA甲基化和组蛋白修饰）可在外源影响下改变基因组功能。从动物模型获得的结果表明，在子宫内或生命早期环境中暴露可产生可以通过世代遗传并伴有表观遗传学改变的效应。在动物模型中寻找表观遗传机制的人类等效物的研究正在进行中。

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《3rd International conference on pollution ecology》|2012年|117|共1页
会议地点 Tianjin(CN)
作者
Andrea Baccarelli;
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作者单位

Department of Environmental Health,Harvard School of Public Health,Boston,MA,USA;

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原文格式 PDF
正文语种 eng
中图分类污染生态学;
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8. Tickborne Diseases of Humans- a History of Environmental and Epidemiological Changes. [R] . Hoogstraal, H. 1977

机译：人类蜱传疾病 - 环境和流行病学变化的历史。

Environmental Epigenetics-Investigating the Environmental Programming of Human Disease

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