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首页> 外文会议>6th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2003) Pt.II; Nov 15-18, 2003; Montreal, Canada >An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects
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An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects

机译：精神分裂症患者侧脑室形态变化的研究

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摘要

We present results of morphometric analysis of the lateral ventricles of a group of schizophrenic and control subjects to investigate possible shape differences associated with schizophrenia. Our results show shape changes localised to three regions : the temporal horn (its tip near the amygdala, and along its body near the parahippocampal fissure), the central part of the lateral ventricles around the corpus cal-losum, and the tip of the anterior horn in the region of the frontal lobe. The differences in the temporal and anterior horns are in regions close to structures thought to be implicated in schizophrenia. The changes observed are the most significant changes (p < 10~(-13)) in shape parameters calculated using a 3D statistical shape descriptor (point distribution model). Corresponding points on the surface of the ventricles in the training set were obtained using an transportation-based method to match high curvature points.
机译：我们目前对一组精神分裂症和对照对象的侧脑室进行形态计量学分析的结果，以调查与精神分裂症相关的可能的形状差异。我们的研究结果显示，形状变化主要分布在三个区域：颞角（靠近杏仁核的尖端，以及靠近海马旁裂隙的身体顶部）、,体周围侧脑室的中央部分以及前侧的尖端额叶区域的角。颞角和前角的差异在接近被认为与精神分裂症有关的结构的区域中。观察到的变化是使用3D统计形状描述符（点分布模型）计算出的形状参数中最显着的变化（p <10〜（-13））。使用基于运输的方法来匹配训练集中的心室表面上的相应点以匹配高曲率点。

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