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首页> 外文会议>6th world congress of biomechanics (WCB 2010) >Involvement of CGRP-Positive Nerve Fibers in Consolidation Stage of Distraction Osteogenesis
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Involvement of CGRP-Positive Nerve Fibers in Consolidation Stage of Distraction Osteogenesis

机译：CGRP阳性神经纤维参与牵张成骨的巩固阶段

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摘要

To investigate the temporal and spatial distribution of calcitonin gene-related peptide (CGRP) positive nerve fibers during the consolidation stage of distraction osteogenesis (DO), twenty New Zealand white rabbits were used for unilateral DO. Distraction started at the 7th day after osteotomy with 1 mm of length per day. The lengthening lasted for 10 days. Four rabbits were sacrificed at each of the following time point at 7-day, 14-day, 21-day, 28-day and 42-day post-distraction. The entire distraction callus and 2 mm of neighboring cortical bone on the proximal and distal sides was removed en bloc for assessments. The results showed that CGRP-positive nerve fibers were observed in the periosteal, intercortical and en-docortical regions at 7-day post-distraction. After that, CGRP-positive nerve fibers were mainly found in the fibrous tissue of periosteal region and bone marrow of bony callus. Moreover, the density of CGRP innervations was significantly higher at 21-day post-distraction than that of other time point. In conclusion, the observed spatial and temporal distribution of CGRP-positive nerve fibers during consolidation stage of DO suggested CGRP innervation is associated with DO.
机译：为了研究降钙素基因相关肽（CGRP）牵张成骨（DO）巩固期的时空分布，将20只新西兰白兔用于单侧DO。截骨术后第7天开始分散注意力，每天长度为1毫米。延长持续了10天。分心后第7天，14天，21天，28天和42天在以下每个时间点处死四只兔子。将整个分散骨的愈伤组织和近端和远端的2 mm的邻近皮质骨整块取出，进行评估。结果显示，分心后7天，在骨膜，皮质间和内膜区观察到CGRP阳性神经纤维。此后，CGRP阳性神经纤维主要存在于骨call的骨膜区和骨髓的纤维组织中。此外，分心后21天的CGRP神经支配密度显着高于其他时间点。总之，在溶解氧的巩固阶段观察到的CGRP阳性神经纤维的时空分布表明CGRP的神经支配与溶解氧有关。

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