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首页> 外文会议>88th Textile Institute world conference 2012 : Bridging innovation, research and enterprise >Development of Hygienic Socks for Patients with Tinea Pedis (Athlete's Foot) through Microencapsulation Technology
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Development of Hygienic Socks for Patients with Tinea Pedis (Athlete's Foot) through Microencapsulation Technology

机译：通过微囊化技术开发用于脚癣患者的卫生袜子

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摘要

Tinea pedis is a common skin disease which affects a large number of the population. It is caused by dermatophytes which are pathogenic fungi that produce keratinase, an enzyme that breaks down keratin, the main constituent of hair, nails and the stratum corneum. Topical agents for tinea pedis normally produce fewer adverse effects than systemic antifungals and for this reason, are considered by many to be the first line treatment for uncomplicated dermatophyte infections. With this, an innovative idea has been initiated by developing a hygienic sock with the integration of microencapsulation technology. Patients with tinea pedis can now undergo medical treatment by the simple action of putting on socks. In this paper, chitosan microcapsules that contain 25 to 100 mg clotrimazole are successfully prepared by using a coacervation technique. The surface morphology, ingredient identification, particle size distribution, and encapsulation efficiency are characterized by scanning electron microscopy (SEM), a particle sizer and high-performance liquid chromatography (HPLC). Cytotoxicity testing is conducted to investigate the toxicology level of the microcapsules. An in-vitro anti-fungal activity analysis confirms that the chitosan/clotrimazole microcapsules show obvious inhibition of Trichophyton rubrum growth.
机译：足癣是一种常见的皮肤病，会影响很多人。它是由皮肤真菌引起的，皮肤真菌是一种致病性真菌，会产生角蛋白酶（一种分解角蛋白的酶），角蛋白是头发，指甲和角质层的主要成分。足癣的局部用药通常比全身性抗真菌药产生的不良反应少，因此，许多人认为这是单纯性皮肤癣菌感染的一线治疗方法。以此为基础，通过集成微囊技术开发一种卫生袜子，人们开始了一个创新的想法。脚癣患者现在可以通过穿袜子的简单动作进行药物治疗。本文通过凝聚技术成功制备了含25至100 mg克霉唑的壳聚糖微胶囊。通过扫描电子显微镜（SEM），粒度仪和高效液相色谱（HPLC）表征表面形态，成分识别，粒度分布和包封效率。进行细胞毒性测试以研究微胶囊的毒理学水平。体外抗真菌活性分析证实，壳聚糖/克霉唑微胶囊对红毛癣菌的生长具有明显的抑制作用。

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