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首页> 外文会议>ACS Symposium Series 890; Symposium on Nanotechnology and the Environment: Applications and Implications; ; >Toxicity of Single-Wall Carbon Nanotubes in the Lungs of Mice Exposed by Intratracheal Instillation
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Toxicity of Single-Wall Carbon Nanotubes in the Lungs of Mice Exposed by Intratracheal Instillation

机译：气管内滴注暴露于小鼠肺中的单壁碳纳米管的毒性

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摘要

Single-wall carbon nanotubes (NTs) are light and could become airborne; fine NT particles could potentially reach the lung. The pulmonary toxicity of three NT products was investigated in mice by intratracheal instillation. Mice (4 to 5 per group) were each instilled once with a fine-particle suspension containing 0, 0.1 or 0.5 mg of NTs or a reference dust (carbon black or quartz), and killed 7 or 90 days later for lung histopathological study. Carbon black elicited minimal effects and high-dose quartz produced mild to moderate inflammation in the lungs. All the three NT products studied produced granulomas (microscopic nodules) and other lung lesions. These results show that, for the test conditions described here and on an equal-weight basis, if NTs reach the lung, they can be more toxic than quartz. If airborne NT dusts are present in the working environment, respiratory protection should be used to minimize inhalation exposures.
机译：单壁碳纳米管（NTs）很轻，可能会通过空气传播。细小的NT颗粒可能会到达肺部。通过气管内滴注研究了三种NT产品的肺毒性。将小鼠（每组4至5只）分别滴入含有0、0.1或0.5 mg NTs或参比粉尘（炭黑或石英）的细颗粒悬浮液一次，并在7天或90天后处死以进行肺组织病理学研究。炭黑的影响最小，高剂量的石英在肺部产生轻度至中度的炎症。研究的所有三种NT产品均产生肉芽肿（微小结节）和其他肺部病变。这些结果表明，对于此处所述的试验条件并以等重为基础，如果NT到达肺部，它们的毒性可能比石英高。如果工作环境中存在空气中的NT尘土，则应使用呼吸防护措施以最大程度减少吸入暴露。

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