Synthesis Based on Affinity Separation: A New Methodology for High-Throughput Synthesis Using Affinity Tags

机译：基于亲和力分离的合成：使用亲和力标签进行高通量合成的新方法

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A new "tag" strategy, termed "synthesis based on affinity separation (SAS)", was developed for high throuput synthesis of organic compounds. In this method, the desired tagged compound was separated from the reaction mixture by solid-phase extraction using specific molecular recognition. The interaction between a crown ether (32-crown-10) and ammonium ion and the interaction between a barbituric acid derivative and its artificial receptor were used for SAS.

机译：已开发出一种新的“标签”策略，称为“基于亲和力分离（SAS）的合成”，用于有机化合物的高通量合成。在该方法中，使用特定分子识别通过固相萃取从反应混合物中分离出所需的标记化合物。 SAS使用冠醚（32-crown-10）与铵离子之间的相互作用以及巴比妥酸衍生物及其人工受体之间的相互作用。

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来源
《ACS Symposium Series 892; Pan-Pacific Conference on Pesticide Science; 20030601-04; Honolulu,HI(US)》|2003年|P.87-98|共12页
会议地点 HonoluluHI(US)
作者
Koichi Fukase; San-Qi Zhang; Yoshiyuki Fukase; Naomi Umesako; Shoichi Kusumoto;
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作者单位

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan;

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原文格式 PDF
正文语种 eng
中图分类农业化学;
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专利

1. Synthesis based on affinity separation (SAS): Separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction [J] . Zhang SQ., Izumi M., Fukase Y., Synlett . 2001,第5期

机译：基于亲和力分离（SAS）的合成：通过氢键相互作用从未标记的化合物中分离具有巴比妥酸标签的产物
2. Synthesis based on affinity separation (SAS): Separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction [J] . Zhang SQ., Izumi M., Fukase Y., Synlett . 2001,第5期

机译：基于亲和力分离（SAS）的合成：通过氢键相互作用从未标记的化合物中分离具有巴比妥酸标签的产物
3. Synthesis and structure-affinity relationships of selective high-affinity 5-HT_4 receptor antagonists: Application to the design of new potential single photon emission computed tomography tracers [J] . Dubost E., Dumas N., Fossey C., Journal of Medicinal Chemistry . 2012,第22期

机译：选择性高亲和力5-HT_4受体拮抗剂的合成与结构亲和关系：在设计新的潜在单光子发射计算机断层扫描示踪剂中的应用
4. Synthesis Based on Affinity Separation: A New Methodology for High-Throughput Synthesis Using Affinity Tags [C] . Koichi Fukase, San-Qi Zhang, Yoshiyuki Fukase, Pan-Pacific Conference on Pesticide Science . 2005

机译：基于亲和分离的合成：使用亲和标签的高通量合成的新方法
5. Synthesis and study of chelating polymers and their application to protein and metal separation from aqueous solutions using novel metal affinity interaction techniques. [D] . Garcia-Barron, Javier Enrique. 1999

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6. Expression Platforms for Producing Eukaryotic Proteins: A Comparison of E. coli Cell-Based and Wheat Germ Cell-Free Synthesis Affinity and Solubility Tags and Cloning Strategies [O] . David J. Aceti, Craig A. Bingman, Russell L. Wrobel, -1

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Synthesis Based on Affinity Separation: A New Methodology for High-Throughput Synthesis Using Affinity Tags

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