• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII >Continuous noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes during hemodialysis in humans: direct comparison with the CRIT-LINE
【24h】

Continuous noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes during hemodialysis in humans: direct comparison with the CRIT-LINE

机译：连续无创体内监测人类血液透析期间血管内血浆容量和血细胞比容的变化：与CRIT-LINE的直接比较

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We report a new device and algorithm that allows simultaneous monitoring of the hematocrit and plasma volume fraction of blood within the intravascular space of an optically probed volume of skin. Skin is probed with a near infrared (NIR) laser and simultaneously collecting the Rayleigh and Mie scattered light as one raw signal and the undifferentiated Raman and fluorescence emission as the second raw signal. These signals are combined using six parameters that can be obtained by either direct calculation or empirical calibration to permit monitoring of the blood in human skin (e.g. fingertips). We tested a device based on the algorithm that might be useful in allowing the early detection of blood loss for people who have no external injury but may be hemorrhaging internally. IRB allowed experiments monitoring blood in human fingertip skin in vivo during routine hemodialysis demonstrated good agreement between the experimental device and the CRIT-LINE~®, an FDA approved device that is built into the dialysis machine and applies the Twersky algorithm to blood in the dialysis machine (i.e. in vitro). Based on observation of 9 different test subjects, as dialysis removes fluid from the intravascular space causing an increase in hematocrit and a decrease in plasma volume, the CRIT-LINE response is closely emulated (typical per session linear correlation r~2=0.78, N=87, p＜0.0001) with the new device. Calibration across subjects, the measurement of absolute hematocrit, and potential confounding factors will also be discussed.
机译：我们报告了一种新的设备和算法，可以同时监视光学探测皮肤体积的血管内空间内的血细胞比容和血浆体积分数。用近红外（NIR）激光探测皮肤，并同时收集瑞利和米氏散射光作为一个原始信号，未分化的拉曼光谱和荧光发射作为第二个原始信号。使用可通过直接计算或经验校准获得的六个参数来组合这些信号，以允许监视人体皮肤中的血液（例如指尖）。我们测试了一种基于该算法的设备，该设备可能有助于在没有外部伤害但可能内部出血的人中及早发现失血。 IRB允许进行常规血液透析期间在体内监测人的指尖皮肤中血液的实验表明，该实验设备与CRIT-LINE〜®之间具有良好的一致性，CRIT-LINE〜®是FDA批准的内置于透析机中的设备，并将Twersky算法应用于透析中的血液机（即体外）。根据对9个不同测试对象的观察，由于透析从血管内腔中清除液体导致血细胞比容增加和血浆容量减少，因此对CRIT-LINE响应进行了近似模拟（典型地，每次会话线性相关性r〜2 = 0.78，N = 87，p ＜0.0001）。还将讨论跨受试者的校准，绝对血细胞比容的测量以及潜在的混杂因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号