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首页> 外文期刊>Blood purification >Estimation of Filtration Coefficients and Circulating Plasma Volume by Continuously Monitoring Hematocrit during Hemodialysis.
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Estimation of Filtration Coefficients and Circulating Plasma Volume by Continuously Monitoring Hematocrit during Hemodialysis.

机译：通过在血液透析过程中连续监测血细胞比容估算过滤系数和循环血浆量。

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BACKGROUND/AIMS: Filtration coefficients (Lp) and plasma volume were estimated in order to investigate whether suppressed Lp associates with intradialytic hypotension and/or diabetic nephropathy. METHODS: Twenty-one patients were evaluated. Nine patients were diabetic (DM) and 12 were nondiabetic (non-DM). Three of DM and 4 of non-DM were prone to dialysis-induced hypotension (hypo(+)) and others (hypo(-)) were not. Changes in hematocrit (Ht) were measured for 60 min after the start of ultrafiltration. Lp and plasma volume at the start of ultrafiltration (Vp0) were estimated to fit calculating values of Ht based on Schneditz's open two compartment model to actual value. RESULTS: There was no significant difference in the mean values of Lp/Vp0 either between hypo(+) and hypo(-) (0.87 +/- 0.37 vs. 1.24 +/- 0.48 ml/mm Hg.min.liter; n.s.) or between DM and non-DM (1.04 +/- 0.32 vs. 1.17 +/- 0.56 ml/mm Hg.min. liter; n.s.). However, the comparisons of Lp/Vp0 among the four groups (hypo(+)/DM, hypo(-)/DM, hypo(+)on-DM and hypo(-)on-DM) showed significant differences between hypo(+)on-DM and hypo(-)on-DM (1.08 +/- 0.40, 1.02 +/- 0.32, 0.71 +/- 0.29*, 1.40 +/- 0.53* ml/mm Hg.min.liter; *p < 0.05). Differences in the percentage of Vp0 to body weight (Vp0/BW) among four groups and correlation between Lp/Vp0 and Vp0/BW were not significant. CONCLUSION: These data indicated that reduction of Lp/Vp0 was not simply caused by decreased circulating plasma volume (Vp0/BW) and that the suppressed filtration coefficients may have substantial association with dialysis-induced hypotension in non-DM. The estimation of Lp using in-line measurement of Ht was a useful method for analyzing intradialytic hypotension.
机译：背景/目的：估计过滤系数（Lp）和血浆容量，以研究抑制的Lp是否与透析内低血压和/或糖尿病性肾病有关。方法：对21例患者进行了评估。 9名糖尿病（DM）患者和12名非糖尿病（non-DM）患者。 DM中的三个和非DM中的四个易于透析引起的低血压（hypo（+）），而其他（hypo（-））则不容易。开始超滤后60分钟，测量血细胞比容（Ht）的变化。根据Schneditz的开放式两室模型，估算超滤开始时的Lp和血浆体积（Vp0）以适合Ht的计算值。结果：hypo（+）和hypo（-）之间的Lp / Vp0平均值无显着差异（0.87 +/- 0.37 vs.1.24 +/- 0.48 ml / mm Hg.min.liter; ns）或介于DM和非DM之间（1.04 +/- 0.32 vs. 1.17 +/- 0.56 ml / mm Hg.min。liter; ns）。但是，四组（hypo（+）/ DM，hypo（-）/ DM，hypo（+）/ non-DM和hypo（-）/ non-DM）之间的Lp / Vp0比较显示，hypo（+）/ DM （+）/非DM和次（-）/非DM（1.08 +/- 0.40，1.02 +/- 0.32，0.71 +/- 0.29 *，1.40 +/- 0.53 * ml / mm汞·最小升; * p ＜0.05）。四组之间Vp0对体重的百分比（Vp0 / BW）的差异以及Lp / Vp0和Vp0 / BW之间的相关性不显着。结论：这些数据表明，Lp / Vp0的降低不是简单地由循环血浆容量（Vp0 / BW）降低引起的，并且抑制的滤过系数可能与非DM透析引起的低血压有很大关系。使用在线测量Ht来估计Lp是分析透析内低血压的有用方法。

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