Imaging System Design for Surgical Guidance with Near-Infrared Autofluorescence

机译：近红外自发荧光手术指导成像系统设计

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We present a study to evaluate and compare three near-infrared (NIR) fluorescence imaging systems designed to provide intraoperative guidance around anatomical structures. The three systems adapted specifically for the application of endogenous NIR fluorescence detection were (1) a photomultiplier tube based NIR viewer, (2) a thermoelectrically cooled electron-multiplying charge-coupled device (CCD) camera, and (3) a clinical endoscope CCD camera system. Each system was evaluated on the basis of ease-of-use, cost, and system performance. The cooled CCD camera showed the highest contrast ratio, but is limited in utility by its bulk interface and high cost. The clinical endoscope camera showed flexibility in its field-of-view and provides the benefit of being sterilized to allow easy integration into the surgical suite; however, it exhibits signal nonlinearity that would distort quantitative analysis. The NIR viewer shows optimal performance, exhibiting high spatial resolution, linearity, and sufficient contrast to differentiate between tissue types. This low-cost design proves to be the optimal system for parathyroid detection, offering ease-of-use in a surgical setting while meeting system performance requirements.

机译：我们提出了一项研究，以评估和比较三个近红外（NIR）荧光成像系统，旨在提供围绕解剖结构的术中指导。专门适用于内源性NIR荧光检测的三个系统是（1）基于光电倍增管的NIR查看器，（2）热电冷却的电子倍增电荷耦合器件（CCD）相机和（3）临床内窥镜CCD摄像系统。根据易用性，成本和系统性能对每个系统进行了评估。冷却的CCD相机显示出最高的对比度，但由于其庞大的接口和高昂的成本而在实用性方面受到限制。临床内窥镜摄像机在其视野中显示出灵活性，并提供了经过消毒的优点，从而可以轻松集成到手术室中。但是，它表现出信号非线性，会扭曲定量分析。 NIR查看器显示最佳性能，具有高空间分辨率，线性和足够的对比度以区分组织类型。这种低成本的设计被证明是甲状旁腺检测的最佳系统，在满足系统性能要求的同时，在外科手术环境中易于使用。

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《Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII》|2015年|931303.1-931303.10|共10页
会议地点 San Francisco CA(US)
作者
Melanie McWade; Isaac Pence; Constantine Paras; Anita Mahadevan-Jansen;
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作者单位

Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee 37235;

Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee 37235;

Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee 37235;

Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee 37235;

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正文语种 eng
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关键词
near-infrared fluorescence; intraoperative imaging; surgical guidance; anatomical imaging; parathyroid detection;

机译：近红外荧光术中成像手术指导；解剖成像甲状旁腺检测;

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机译：绿光自发荧光与联合蓝光自发荧光和近红外反射率成像在中学与年龄相关的黄斑变性（Vol 58，PG Bio121,2017）
2. Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration [J] . Maximilian Pfau, Lukas Goerdt, Steffen Schmitz-Valckenberg, Investigative ophthalmology & visual science . 2017,第6期

机译：绿光自发荧光与结合蓝光自发荧光和近红外反射成像在继发于年龄相关性黄斑变性的地理萎缩中
3. Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration [J] . Pfau Maximilian, Goerdt Lukas, Schmitz-Valckenberg Steffen, Investigative ophthalmology & visual science . 2017,第6期

机译：绿色轻荧光与组合蓝光自发荧光和近红外反射率成像在地理萎缩中，继发于年龄相关的黄斑变性
4. Imaging System Design for Surgical Guidance with Near-Infrared Autofluorescence [C] . Melanie McWade, Isaac Pence, Constantine Paras, Conference on Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems . 2015

机译：近红外自发荧光的手术指导成像系统设计
5. Intraoperative Multimodal Imaging System for Surgical Guidance. [D] . Popovic, Kosta. 2013

机译：术中术中多模态成像系统的手术指导。
6. Real-time Near-Infrared Fluorescence Imaging with an Optimized Dye/Light Source/Camera Combination for Surgical Guidance of Prostate Cancer [O] . Brian P. Neuman, John B. Eifler, Mark Castanares, -1

机译：实时近红外荧光成像和优化的染料/光源/相机组合用于前列腺癌的手术指导
7. Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration [O] . Maximilian Pfau, Lukas Goerdt, Steffen Schmitz-Valckenberg, 2017

机译：绿色轻荧光与组合蓝光自发荧光和近红外反射率成像在地理萎缩中，继发于年龄相关的黄斑变性

Imaging System Design for Surgical Guidance with Near-Infrared Autofluorescence

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