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首页> 外文会议>Advanced biomedical and clinical diagnostic systems IX >Investigation of source-detector separation optimization for an implantable perfusion and oxygenation sensor for liver blood vessels
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Investigation of source-detector separation optimization for an implantable perfusion and oxygenation sensor for liver blood vessels

机译：肝血管植入式充氧传感器的源-检测器分离优化研究

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An implanted system is being developed to monitor transplanted liver health during the critical 7-10 day period post-transplantation. The unit will monitor organ perfusion and oxygen consumption using optically-based probes placed on both the inflow and outflow blood vessels, and on the liver parenchymal surface. Sensing probes are based on a 3-wavelength LED source and a photodiode detector. Sample diffuse reflectance is measured at 735, 805, and 940 nm. To ascertain optimal source-to-photodetector spacing for perfusion measurement in blood vessels, an ex vivo study was conducted. In this work, a dye mixture simulating 80% blood oxygen saturation was developed and perfused through excised porcine arteries while collecting data for various preset probe source-to-photodetector spacings. The results from this study demonstrate a decrease in the optical signal with decreasing LED drive current and a reduction in perfusion index signal with increasing probe spacing. They also reveal a 2- to 4-mm optimal range for blood vessel perfusion probe source-to-photodetector spacing that allows for sufficient perfusion signal modulation depth with maximized signal to noise ratio (SNR). These findings are currently being applied to guide electronic configuration and probe placement for in vivo liver perfusion porcine model studies.
机译：正在开发一种植入系统，以在移植后的关键7-10天期间监控移植肝脏的健康状况。该装置将使用光学探针监测器官灌注和耗氧量，该探针放置在流入和流出血管以及肝实质表面上。传感探头基于3波长LED光源和光电二极管检测器。在735、805和940 nm处测量样品的漫反射率。为了确定用于血管中灌注测量的最佳光源到光电探测器的间距，进行了离体研究。在这项工作中，开发了一种模拟血氧饱和度为80％的染料混合物，并通过切除的猪动脉进行灌注，同时收集各种预设探针源到光电探测器间距的数据。这项研究的结果表明，随着LED驱动电流的减小，光信号的减小；随着探头间距的增加，灌注指数信号的减小。他们还揭示了血管灌注探头源到光电探测器间距的2至4 mm最佳范围，该范围允许足够的灌注信号调制深度，并具有最大的信噪比（SNR）。这些发现目前正在用于指导体内肝脏灌注猪模型研究的电子配置和探针放置。

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