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A combined time-domain diffuse fluorescence and optical tomography system for breast tumor detection

机译：组合时域漫射荧光和光学层析成像系统，用于乳腺肿瘤检测

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摘要

A combined time-domain diffuse fluorescence and optical tomographic system is proposed based on the multi-channel time-correlated single-photon counting (TCSPC) technique, aiming at enhancing the reliability of breast diffuse optical tomography. The system equipped with two pulsed laser diodes at wavelengths of 780 nm and 830 nm that are specific to the maximal excitation and emission of the FDA-approved ICG dye, and works with a 4-channel TCSPC module to acquire the temporal distributions of the light re-emissions 32 boundary sites of tissues in a tandem serial-to-parallel mode. The performance and efficacy of the system are investigated with phantom experiments for diffuse optical tomography (DOT), as well as fluorescence-guided DOT.
机译：提出了一种基于多通道时间相关单光子计数（TCSPC）技术的时域漫射荧光与光学层析成像相结合的系统，旨在提高乳腺漫射光学层析成像的可靠性。该系统配备了两个脉冲激光二极管，分别用于FDA批准的ICG染料的最大激发和发射，波长分别为780 nm和830 nm，并与4通道TCSPC模块配合使用以获取光的时间分布以串联-并联方式重新发射组织的32个边界部位。该系统的性能和功效已通过用于扩散光学层析成像（DOT）的幻影实验以及荧光引导的DOT进行了研究。

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  • 来源
    《Advanced biomedical and clinical diagnostic systems X》|2012年|p.82141B.1-82141B.11|共11页
  • 会议地点 San Francisco CA(US)
  • 作者

    Wei Zhang; Feng Gao; Linhui Wu; Wenjuan Ma; Yiming Lu; Zhongxing Zhou;

  • 作者单位

    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;

    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China,Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China;

    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;

    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;

    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;

    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China,Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
  • 关键词

    multi-channel time-resolved system; time-correlated single photon counting; fluorescence diffuse optical tomography;

    机译：多通道时间解析系统；时间相关的单光子计数；荧光扩散光学层析成像;

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