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In-vitro observation of cartilage-degeneration progression by Fourier-domain OCT

机译：傅里叶域OCT体外观察软骨退化进程

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摘要

Optical Coherence Tomography (OCT) as emerging clinical diagnostic imaging technology for dermatology and other semitransparent tissues has shown high potential in monitoring and evaluating the inner structure of articular cartilages. Since novel therapies for the limitation of cartilage degeneration in early stages of osteoarthritis are available, the early minimal invasive diagnosis of cartilage degradation is clinically essential for further treatment options. With the advancing performance and thus diagnostic opportunities of 3D-OCT devices, we carried out a systematic study by monitoring arthrotic alterations of porcine osteochondral explants that are mechanically induced under traumatic impaction. As for in-vitro tomographic imaging we utilized two OCT devices, a Thorlabs FD-OCT device with 92KHz A-scan rate and 1310nm as central wavelength and a self-developed FD-OCT device at 840nm central wavelength. This allows the comparison in image contrast and optical penetration of cartilage tissue between these two spectral bandwidths. Further we analyzed human biopsies of articular cartilages with various degrees of osteoarthritis. The 2D and 3D OCT tomograms are characterized qualitatively regarding the inner tissue structure and quantitatively regarding the tissue absorption parameters. Therefore, we are developing image processing algorithms for the automated monitoring of cartilage tissue. A scoring system for 3D-monitoring allows the characterization of the probe volume regarding the morphological structure and tissue compactness by processing the C - scan data.
机译：作为皮肤病学和其他半透明组织的新兴临床诊断成像技术，光学相干断层扫描（OCT）在监测和评估关节软骨的内部结构方面显示出很高的潜力。由于可以使用限制骨关节炎早期软骨变性的新疗法，因此对软骨退化的早期微创诊断在临床上对于进一步的治疗选择至关重要。随着3D-OCT设备性能的提高以及由此带来的诊断机会，我们通过监测在外伤性撞击下机械诱导的猪骨软骨外植体的关节炎变化，进行了系统的研究。对于体外层析成像，我们使用了两种OCT设备：Thorlabs FD-OCT设备（中心波长为92KHz，扫描波长为1310nm）和自行研发的FD-OCT设备，中心波长为840nm。这允许比较这两个光谱带宽之间的图像对比度和软骨组织的光学渗透。此外，我们分析了人类关节软骨与不同程度的骨关节炎的活检。 2D和3D OCT断层图像的特征在于内部组织结构，定量地表征组织吸收参数。因此，我们正在开发用于自动监测软骨组织的图像处理算法。用于3D监控的评分系统可通过处理C扫描数据来表征与形态结构和组织紧密度有关的探针体积。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Ulrich Marx; Robert Schmitt; Sven Nebelung; Markus Tingart; Christian Luering; Bjoern Rath;

  • 作者单位

    Fraunhofer Institute for Production Technology IPT, Steinbachstr, 17, 52074 Aachen, Germany;

    Fraunhofer Institute for Production Technology IPT, Steinbachstr, 17, 52074 Aachen, Germany,Laboratory for Machine Tools and Production Engineering WZL, RWTH Aachen University, Steinbachstrasse 19, 52074 Aachen, Germany;

    Aachen University Hospital, Department of Orthopaedic Surgery, Pauwelsstrasse 30, 52074 Aachen, Germany;

    Aachen University Hospital, Department of Orthopaedic Surgery, Pauwelsstrasse 30, 52074 Aachen, Germany;

    Aachen University Hospital, Department of Orthopaedic Surgery, Pauwelsstrasse 30, 52074 Aachen, Germany;

    Aachen University Hospital, Department of Orthopaedic Surgery, Pauwelsstrasse 30, 52074 Aachen, Germany;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
  • 关键词

    optical coherence tomography; OCT; osteoarthritis; cartilage degeneration; articular cartilage;

    机译：光学相干断层扫描；华侨城;骨关节炎;软骨变性关节软骨;

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