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Tetra sulfunated nickel phthalocyanine assemblies and its binding to human serum albumin

机译：四磺化镍酞菁镍装配体及其与人血清白蛋白的结合

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The physicochemical properties of Ni (II) sodium tetra sulfunated phthalocyanine, NiPcTS, were investigated at different experimental conditions such as various concentrations of NiPc and ionic strength inlOmM phosphate buffer, pH 7.4 at 25°C. The results show the low tendency of this phthalocyanine for formation of assembles due to increasing of concentration and the formation of H-type aggregate as a result of increasing ionic strength.rnThe interaction of NiPcTS with human serum albumin (HSA) was also studied by Uv-Vis spectroscopic technique in various molar ratios at different temperature and ionic strength. The results represent the formation of a 1:1 complex from HSA -NiPcTS and the predominant role of electrostatic forces in the interaction. The binding constants (K) were obtained by analysis of optical absorption spectra of mentioned complex at various HSA concentrations using SQUAD software while the thermodynamic parameters were calculated by van't Hoff equation.

机译：在不同的实验条件下（例如各种NiPc浓度和10mM磷酸盐缓冲液中离子强度，pH 7.4在25°C下）研究了Ni（II）四磺化酞菁钠NiPcTS的理化性质。结果表明，由于浓度增加和离子强度增加导致H型聚集体形成的原因，这种酞菁形成组装体的可能性较低.rnUv还研究了NiPcTS与人血清白蛋白（HSA）的相互作用-可见光谱技术，在不同的摩尔比下，在不同的温度和离子强度下。结果表示由HSA -NiPcTS形成1：1的络合物以及静电力在相互作用中的主要作用。通过使用SQUAD软件分析上述配合物在各种HSA浓度下的光吸收光谱，获得结合常数（K），并通过van't Hoff方程计算热力学参数。

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来源
《Advances in biomedical research》|2010年|p.493-497|共5页
会议地点 Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB)
作者
SHAMM FARSHAD; ABDOL-KHALEGH BORDBAR; HOSSEIN AGHAEI; KARIM ZARA;
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作者单位

Azad University, Science and Research Campus, Hesarak, TehranrnIRAN;

rnLaboratory of Biophysical Chemistry, Chemistry Department University of Isfahan, Hezar Jereeb Street, IsfahanrnIRAN;

Azad University, Science and Research Campus, Hesarak, TehranrnIRAN;

Azad University, Science and Research Campus, Hesarak, TehranrnIRAN;

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原文格式 PDF
正文语种 eng
中图分类生物医学工程;
关键词
Human serum albumin; Phthalocyanine; Thermodynamic of binding; Optical absorption;

机译：人血清白蛋白；酞菁;结合的热力学；光学吸收;

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1. Spectroscopy and Molecular Modeling Study on Binding of Nickel Phthalocyanine to Human Serum Albumin [J] . Dezhampanah Hamid, Firouzi Roghaye, Hasani Leila Protein and peptide letters . 2016,第9期

机译：酞菁镍与人血清白蛋白结合的光谱学和分子模型研究
2. Intermolecular interaction of nickel (ii) phthalocyanine tetrasulfonic acid tetrasodium salt with bovine serum albumin: A multi-technique study [J] . Dezhampanah Hamid, Firouzi Roghaye, Hasani Leila Nucleosides, nucleotides and nucleic acids . 2017,第1a3期

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3. Nickel(II) transport in human blood serum. Studies of nickel(II) binding to human albumin and to native-sequence peptide, and ternary-complex formation with l-histidine [J] . Bibudhendra Sarkar, Jeremy D. Glennon The biochemical journal . 1982,第1期

机译：镍（II）在人血清中的转运。镍（II）与人白蛋白和天然序列肽结合的研究以及与L-组氨酸形成三元复合物的研究
4. Tetra sulfunated nickel phthaiocyanine assemblies and its binding to human serum albumin [C] . SHAMIM FARSHAD, ABDOL-KHALEGH BORDBAR, HOSSEIN AGHAEI, WSEAS International Conference on Mathematical Biology and Ecology . 2010

机译：Tetra硫化镍酞菁组件及其与人血清白蛋白的结合
5. A Fluorescence Quenching Study of the Human Serum Albumin-Quercetin Complex by Addition of Copper(II), Nickel(II), and Manganese(II) [D] . Kim, Chonghag 2011

机译：铜（II），镍（II）和锰（II）对人血清白蛋白-槲皮素复合物的荧光猝灭研究
6. Nickel(II) transport in human blood serum. Studies of nickel(II) binding to human albumin and to native-sequence peptide and ternary-complex formation with l-histidine [O] . Jeremy D. Glennon, Bibudhendra Sarkar 1982

机译：镍（II）在人血清中的转运。镍（II）与人白蛋白和天然序列肽结合的研究以及与L-组氨酸的三元复合物形成
7. Nickel(II) transport in human blood serum. Studies of nickel(II) binding to human albumin and to native-sequence peptide, and ternary-complex formation with l-histidine [O] . Glennon, Jeremy D., Sarkar, Bibudhendra 1982

机译：镍（II）在人血清中的转运。镍（II）与人白蛋白和天然序列肽结合的研究以及与L-组氨酸的三元复合物形成

Tetra sulfunated nickel phthalocyanine assemblies and its binding to human serum albumin

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