Tetra sulfunated nickel phthaiocyanine assemblies and its binding to human serum albumin

机译：Tetra硫化镍酞菁组件及其与人血清白蛋白的结合

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The physicochemical properties of Ni (II) sodium tetra sulfunated phthaiocyanine, NiPcTS, were investigated at different experimental conditions such as various concentrations of NiPc and ionic strength in 10mM phosphate buffer, pH 7.4 at 25°C. The results show the low tendency of this phthaiocyanine for formation of assembles due to increasing of concentration and the formation of H-type aggregate as a result of increasing ionic strength. The interaction of NiPcTS with human serum albumin (HSA) was also studied by Uv-Vis spectroscopic technique in various molar ratios at different temperature and ionic strength. The results represent the formation of a 1:1 complex from HSA -NiPcTS and the predominant role of electrostatic forces in the interaction. The binding constants (K) were obtained by analysis of optical absorption spectra of mentioned complex at various HSA concentrations using SQUAD software while the thermodynamic parameters were calculated by van't Hoff equation.

机译：在不同的实验条件下在不同的实验条件下研究了Ni（II）钠Tetra硫化酞菁，NiPCT的物理化学性质，例如在10mM磷酸盐缓冲液中的各种浓度的NIPC和离子强度，pH 7.4处在25℃下。结果表明，由于浓度的增加，由于不断增加的离子强度，因此由于浓度的增加和H型聚集体的形成而形成组装的低趋势。在不同温度和离子强度的各种摩尔比中，还通过UV-Vis光谱技术研究了NIPCT与人血清白蛋白（HSA）的相互作用。结果表示从HSA -NIPCTS形成1：1复合物，以及静电力在相互作用中的主要作用。通过使用Squad软件在各种HSA浓度下分析所提到的络合物的光学吸收光谱获得结合常数（K），而通过Vane'tHoff等式计算热力学参数。

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《WSEAS International Conference on Mathematical Biology and Ecology》|2010年||共5页
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SHAMIM FARSHAD; ABDOL-KHALEGH BORDBAR; HOSSEIN AGHAEI; KARIM ZARA;
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中图分类 Q81-53;
关键词
Human serum albumin; Phthaiocyanine; Thermodynamic of binding; Optical absorption;

机译：人血清白蛋白;酞菁;热力结合;光学吸收;

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1. Nickel(II) transport in human blood serum. Studies of nickel(II) binding to human albumin and to native-sequence peptide, and ternary-complex formation with l-histidine [J] . Bibudhendra Sarkar, Jeremy D. Glennon The biochemical journal . 1982,第1期

机译：镍（II）在人血清中的转运。镍（II）与人白蛋白和天然序列肽结合的研究以及与L-组氨酸形成三元复合物的研究
2. High-performance frontal analysis of the binding of thyroxine enantiomers to human serum albumin binding of thyroxine enantiomers to human serum albumin kimura. [J] . Kimura T, Nakanishi K, Nakagawa T, Pharmaceutical research . 2005,第4期

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4. Tetra sulfunated nickel phthaiocyanine assemblies and its binding to human serum albumin [C] . SHAMIM FARSHAD, ABDOL-KHALEGH BORDBAR, HOSSEIN AGHAEI, WSEAS International Conference on Mathematical Biology and Ecology . 2010

机译：Tetra硫化镍酞菁组件及其与人血清白蛋白的结合
5. A Fluorescence Quenching Study of the Human Serum Albumin-Quercetin Complex by Addition of Copper(II), Nickel(II), and Manganese(II) [D] . Kim, Chonghag 2011

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6. Nickel(II) transport in human blood serum. Studies of nickel(II) binding to human albumin and to native-sequence peptide and ternary-complex formation with l-histidine [O] . Jeremy D. Glennon, Bibudhendra Sarkar 1982

机译：镍（II）在人血清中的转运。镍（II）与人白蛋白和天然序列肽结合的研究以及与L-组氨酸的三元复合物形成
7. Nickel(II) transport in human blood serum. Studies of nickel(II) binding to human albumin and to native-sequence peptide, and ternary-complex formation with l-histidine [O] . Glennon, Jeremy D., Sarkar, Bibudhendra 1982

机译：镍（II）在人血清中的转运。镍（II）与人白蛋白和天然序列肽结合的研究以及与L-组氨酸的三元复合物形成

Tetra sulfunated nickel phthaiocyanine assemblies and its binding to human serum albumin

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