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首页> 外文会议>Advances in biomedical research >LIPOSOMES IN DIAGNOSIS OF TUBERCULOSIS
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LIPOSOMES IN DIAGNOSIS OF TUBERCULOSIS

机译：脂质体诊断肺结核

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Tuberculosis is the second most infectious disease and is the leading cause of death in the tropical World. The Mycobacterium tuberculosis infects about 1.7 billion people every year and is responsible for more than 2 million deaths globally each year. Overall, one-third of the world's population is currently infected with the M. tb bacillus without demonstrable symptoms. A delayed or missed diagnosis of active infection and prevalence of drug resistant strains of M. tuberculosis are major causes of transmission and mortality. With the threat of such an epidemic looming, and despite an enormous amount of research since the time of Koch, we still have no simple, rapid, sensitive, and specific test to detect and differentiate most or all patients with active tuberculosis from those with quiescent lesions, previous vaccination, or other diseases, or even from those who are completely healthy. Tuberculosis co-infected with HIV has further complicated the diagnosis since. HIV-positive patients with active TB are more likely to have negative sputum smears and atypical chest X-rays than their HFV-negative counterparts. Timely and accurate identification of subjects infected with M. tuberculosis and rapid laboratory confirmation of tuberculosis are two effective public health measures that can be taken to combat the tuberculosis epidemic across the globe. The focus of this paper is to review the diagnostic potential of proteinaceous and non-proteinaceous antigens in various diagnostic assays and promises of liposome based antibody or antigen detection methods for diagnosis of tuberculosis infection.
机译：结核病是第二大传染病，是热带世界死亡的主要原因。结核分枝杆菌每年感染约17亿人，每年导致全球200万人死亡。总体而言，目前世界上有三分之一的人口感染了结核分枝杆菌，但没有明显的症状。活动性感染的延迟或漏诊诊断和结核分枝杆菌耐药菌株的流行是传播和死亡的主要原因。面对这种流行病的威胁，尽管自科赫时代以来已进行了大量研究，但我们仍然没有简单，快速，灵敏且特异的检测方法来检测和区分大多数或所有活动性结核病患者和静止期患者病变，以前的疫苗接种或其他疾病，甚至来自完全健康的人。此后，与HIV共同感染的结核病使诊断更加复杂。与HFV阴性的患者相比，活动性TB的HIV阳性患者更可能具有阴性的痰涂片和非典型胸部X线照片。及时，准确地鉴定感染结核分枝杆菌的受试者和迅速对结核病进行实验室确认是可以采取的两种有效的公共卫生措施，可以用来对抗全球的结核病流行。本文的重点是综述蛋白质和非蛋白质抗原在各种诊断方法中的诊断潜力，以及基于脂质体的抗体或抗原检测方法在结核感染诊断中的前景。

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