Membrane proteins embedded in supported lipid bilayers employed in field effect electronic devices

机译：嵌入场效应电子设备中支持的脂质双层中的膜蛋白

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A novel bottom-gate top-contact OTFT architecture has been fabricated. In this device, a lipid bilayer structure embedding a photosynthetic membrane protein extracted from Rhodobacter Sphaeroides has been deposited onto the organic semiconductor film (alpha,omega-dihexylsexythiophene) prior to the evaporation of source and drain gold contacts. The figures of merit of this device were extracted and compared to those obtained for the same OTFT devoid of the biological film. Only slightly lower performances in terms of field-effect mobility (mu) were observed for the lipid bilayer OTFT that exhibits mu = 0.007 cm²/Vs. This result constitutes a preliminary important starting point towards the development of novel highly sensitive and selective herbicides sensors.

机译：已经制造了新颖的底栅顶部接触OTFT架构。在该装置中，嵌入源于球形红细菌的光合膜蛋白的脂质双层结构已经沉积在有机和半导体膜（α，ω-二己基己基噻吩）上，然后蒸发了源和漏金触点。提取该装置的品质因数，并将其与没有生物膜的相同OTFT获得的品质因数进行比较。对于显示为mu = 0.007 cm ^{2 / Vs的脂质双层OTFT，在场效应迁移率（μ）方面仅观察到稍低的性能。该结果构成了开发新型高度敏感和选择性除草剂传感器的重要的初步重要起点。}

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《Advances in sensors and Interfaces, 2009. IWASI 2009》|2009年|218-221|共4页
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Angione M.D.; Mallardi A.; Romanazzi G.; Suranna G.P.; Mastrorilli P.; Cafagna D.; De Giglio E.; Palazzo G.; Torsi L.;
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Dipt. di Chimica, Univ. degli Studi di Bari, Bari, Italy;

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biomembranes; biosensors; field effect devices; lipid bilayers; microorganisms; molecular biophysics; organic semiconductors; proteins; Rhodobacter Sphaeroides; alpha,omega-dihexylsexythiophene; bottom-gate top-contact OTFT; field effect electronic devices; field-effect mobility; membrane proteins; organic semiconductor film; photosynthesis;

机译：生物膜;生物传感器;场效应器件;脂质双层;微生物;分子生物物理学;有机半导体;蛋白质;球形红球菌;α，ω-二己基异噻吩;底栅顶部接触OTFT;场效应电子器件;场效应迁移率;膜蛋白有机半导体膜光合作用;

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1. Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core [J] . Brian P. Ziemba, Joseph J. Falke Chemistry and Physics of Lipids . 2013,第Null期

机译：外围膜蛋白在支持的脂质双层上的侧向扩散受（1）结合脂质和（2）渗透到双层烃核中的蛋白域的加性摩擦阻力控制
2. Exploration of interactions between membrane proteins embedded in supported lipid bilayers and their antibodies by reflectometric interference spectroscopy-based sensing [J] . Yoshikazu Kurihara, Tsuneo Sawazumi, Toshifumi Takeuchi The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2014,第22期

机译：通过基于反射干涉光谱的传感探索支持的脂质双层中嵌入的膜蛋白与其抗体之间的相互作用
3. Affinity Capturing and Surface Enrichment of a Membrane Protein Embedded in a Continuous Supported Lipid Bilayer [J] . Dr. Stefan Geschwindner, Nuno M. Basílio, R?mulo Augusto Andrade de ALMEIDA, ChemistryOpen . 2016,第5期

机译：嵌入连续支持的脂质双层中的膜蛋白的亲和力捕获和表面富集
4. Membrane Proteins Embedded in Supported Lipid Bilayers Employed in Field Effect Electronic Devices [C] . M. D. Angione, A. Mallardi, G. Romanazzi, International Workshop on Advanced in Sensors and Interface . 2009

机译：嵌入在现场效果电子器件中的负载脂质双层中嵌入的膜蛋白
5. Studying Lipid-Protein Interaction Using Proteinacous Supported Lipid Bilayers from Cell Membranes. [D] . Hsia, Chih-Yun. 2017

机译：使用细胞膜中蛋白质支持的脂双层来研究脂蛋白相互作用。
6. Lateral Diffusion of Peripheral Membrane Proteins on Supported Lipid Bilayers Is Controlled by the Additive Frictional Drags of 1) Bound Lipids and 2) Protein Domains Penetrating into the Bilayer Hydrocarbon Core [O] . Brian P. Ziemba, Joseph J. Falke -1

机译：外围膜蛋白在支持的脂质双层上的横向扩散受1）结合脂质和2）渗透到双层烃核中的蛋白质结构域的累加摩擦阻力控制
7. Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core [O] . Brian P. Ziemba, Joseph J. Falke 2013

机译：背侧膜蛋白在负载的脂质双层上的横向扩散由（1）结合的脂质和（2）蛋白质结构域穿透到双层烃芯中的添加剂摩擦阻力来控制
8. Bilayer Lipid Membrane-Supported Electronic Devices. [R] . Fendler, J. H. 1989

机译：双层脂质膜支持的电子设备。

Membrane proteins embedded in supported lipid bilayers employed in field effect electronic devices

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