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Chapter 4 Dermal Precursors and the Origins of the Wound Fibroblast

机译:第4章皮肤前体与伤口成纤维细胞的起源

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Tissue repair demands the efficient restoration of connective tissue integrity and architecture. The brunt of the task falls on the fibroblast, a cell type strongly committed to the production of extracellular matrix. Recent investigation has refined the historical concept that the bone marrow and circulating precursors can make a significant, transient contribution to wound healing during the formation of granulation tissue. In parallel, there is mounting evidence that a subset of dermal mesenchymal cells have pluripotent properties that could contribute to the restoration and even regeneration of wound sites. The interrelationships between mesenchymal stem cells, circulating fibrocytes, and dermal progenitors are still an evolving area of investigation. Nevertheless, the manipulation of these cell types for wound healing and tissue engineering applications is a promising strategy.
机译:组织修复需要有效恢复结缔组织的完整性和结构。首当其冲的是成纤维细胞,成纤维细胞是一种强烈致力于细胞外基质产生的细胞类型。最近的研究完善了这样的历史概念,即骨髓和循环前体可以在肉芽组织形成过程中对伤口愈合做出重大而短暂的贡献。同时,越来越多的证据表明,真皮间充质细胞的一部分具有多能性,可以促进伤口部位的恢复甚至再生。间充质干细胞,循环纤维细胞和真皮祖细胞之间的相互关系仍然是一个不断发展的研究领域。然而,为伤口愈合和组织工程应用操纵这些细胞类型是一种有前途的策略。

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