摘要:目的:探讨独活寄生汤联合康复治疗对腰椎间盘突出症的临床疗效,并总结护理经验。方法选择2013年至2014年收治的腰椎间盘突出症患者112例,按随机数字表法分为对照组和观察组,各56例。两组患者均给予常规治疗及护理干预,对照组患者在此基础上结合康复治疗,观察组患者在对照组基础上加用独活寄生汤,两组患者均治疗2周。治疗后,对比两组患者的临床疗效;治疗前后采用疼痛视觉模拟(VAS)评分评价疼痛程度,并检测血清前列腺素E2(PGE2)、白细胞介素(IL )-1β、IL-6、肿瘤坏死因子-α(TNF-α)水平,记录不良反应的发生情况。结果治疗后,两组患者VAS评分均较治疗前显著降低,且观察组显著低于对照组( P<0.05);两组患者血清PGE2、IL-1β、IL-6、TNF-α水平均较治疗前显著降低,且观察组降低幅度均显著大于对照组( P<0.05);观察组总有效率为94.64%,显著高于对照组的76.79%( P<0.05);两组患者治疗中均出现不良反应,故不能肯定不良反应是否完全与独活寄生汤有关,且所有不良反应症状均较轻微,不影响治疗,两组不良反应发生率比较,差异无统计学意义( P>0.05)。结论独活寄生汤联合康复措施治疗腰椎间盘突出症,临床疗效好,能显著缓解疼痛,不良反应少,配合适当的护理干预能提高患者的依从性,保证治疗的顺利进行,值得临床推广。%Objective To investigate the clinical efficacy of Duhuojisheng Decoction combined with rehabilitation therapy on lumbar disc herniation. Methods 112 cases of patients with lumbar disc herniation from January 2013 to December 2013 were divided into the control group and the observation group according to the random number table method,56 cases in each group. The two groups were given routine treatment and nursing intervention,on the this basis,the control group was combined with rehabilitation therapy,and the observation group was added with Duhuojisheng Decoction on the basis of the control group. The two groups were treated for 2 weeks. After treatment,the clinical efficacies of the two groups were compared,the VAS scores were used to evaluate the degree of pain before and after treatment,and the prostaglandin ( PGE2 ) ,serum interleukin ( IL ) -1β,IL-6,tumor necrosis factor-α( TNF-α) levels were detected,the occurrence rates of adverse reactions were recorded. Results After treatment,the VAS scores of the two groups were significantly reduced compared with before treatment,and the observation group was significantly lower than the control group ( P < 0. 05 ) . The serum PGE2,IL-1β,IL-6,TNF-α levels of the two groups were significantly reduced,the and reduction in the observation group were greater than the control group ( P < 0. 05 ) . The total effective rate of the observation group was 94. 64%,which was significantly higher than 76. 79% of the control group ( P < 0. 05 ) . Adverse reactions occurred in the treatment of two groups,so it couldn′t be cer-tain that the adverse reactions were related to Duhuojisheng Decoctine. Also,all adverse reactions were mild,and didn′t affect the treat-ment. The incidence rate of the adverse reactions in the two groups had no statistical difference ( P > 0. 05 ) . Conclusion Duhuojisheng Decoctine combined with rehabilitation therapy in treating lumbar disc herniation has good clinical efficacy,can significantly relieve pain with less adverse reaction. If combined with proper nursing,it can improve the patients′ compliance,ensure the smooth progress of treat-ment,which is worthy of clinical promotion.