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首页> 外文会议>Advances in structures, properties and applications of biological and bioinspired materials >Identifying Iron Oxide Based Materials that Can Either Pass or Not Pass through the in vitro Blood-Brain Barrier
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Identifying Iron Oxide Based Materials that Can Either Pass or Not Pass through the in vitro Blood-Brain Barrier

机译：识别可以通过或不通过体外血脑屏障的氧化铁基材料

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摘要

In this study, an in vitro blood-brain barrier model was developed using murine brain endothelioma cells (b.End3 cells). By comparing the permeability of FITC-Dextran at increasing exposure times in serum-free medium to such values in the literature, we confirm that the blood-brain barrier model was successfully established. After such confirmation, the permeability of five ferrofluid (FF) nanoparticle samples, GGB (ferrofluid synthesized using glycine, glutamic acid and BSA), GGC (glycine, glutamic acid and collagen), GGP (glycine, glutamic acid and PVA), BPC (BSA, PEG and collagen) and CPB (collagen, PVA and BSA), was determined using this model In addition, all the five FF samples were characterized by zeta potential to determine their charge as well as TEM and dynamic light scattering for determining their hydrodynamic diameter Results showed that FF coated with collagen had better permeability to the blood-brain barrier than FF coated with glycine and glutamic acid based on an increase of 4.5% in permeability. Through such experiments, magnetic nanomaterials, such as ferrofluids, that are less permeable to the blood brain barrier can be used to decrease neural tissue toxicity and magnetic nanomaterials with more permeable to the blood-brain barrier can be used for brain drug delivery.
机译：在这项研究中，使用鼠脑内皮细胞瘤细胞（b.End3细胞）建立了体外血脑屏障模型。通过比较在无血清培养基中增加暴露时间的FITC-右旋糖酐的渗透性与文献中的此类值，我们证实血脑屏障模型已成功建立。经过这样的确认，五个铁磁流体（FF）纳米颗粒样品，GGB（使用甘氨酸，谷氨酸和BSA合成的铁磁流体），GGC（甘氨酸，谷氨酸和胶原蛋白），GGP（甘氨酸，谷氨酸和PVA），BPC（使用此模型测定BSA，PEG和胶原蛋白）和CPB（胶原蛋白，PVA和BSA）。此外，所有五个FF样品均通过zeta电位进行表征，以确定其电荷以及TEM和动态光散射以确定其流体动力学直径结果表明，胶原蛋白包被的FF对血脑屏障的通透性比甘氨酸和谷氨酸包被的FF高4.5％。通过这样的实验，对血脑屏障渗透性较低的磁性纳米材料（例如铁磁流体）可用于降低神经组织毒性，而对血脑屏障渗透性更高的磁性纳米材料可用于脑部药物递送。

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  • 会议地点 Boston MA(US)
  • 作者

    Di Shi; Linlin Sun; Gujie Mi; Soumya Bhattacharya; Suprabha Nayar; Thomas J Webster;

  • 作者单位

    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA;

    Department of Bioengineering, Northeastern University, Boston, MA 02115, USA;

    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA;

    Materials Science and Technology Division, CSIR-National Metallurgical Laboratory, Jamshedpur, JH 831007, India;

    Materials Science and Technology Division, CSIR-National Metallurgical Laboratory, Jamshedpur, JH 831007, India;

    Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA;

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  • 正文语种 eng
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