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首页> 外文会议>Advances in structures, properties and applications of biological and bioinspired materials >In Vitro Examination of Poly(glycerol sebacate) Degradation Kinetics: Effects of Porosity and Cure Temperature
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In Vitro Examination of Poly(glycerol sebacate) Degradation Kinetics: Effects of Porosity and Cure Temperature

机译：聚癸二酸甘油酯降解动力学的体外研究：孔隙率和固化温度的影响

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摘要

Poly(glycerol sebacate) (PGS) is a biodegradable and biocompatible elastomer that has been used in a wide range of biomedical applications. While a porous format is common for tissue engineering scaffolds, to allow cell ingrowth, PGS degradation has been primarily studied in a nonporous format. The purpose of this research was to investigate the degradation of porous PGS at three frequently used cure temperatures: 120℃, 140℃, and 165℃. The thermal, chemical, mechanical, and morphological changes were examined using thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, compression testing, and scanning electron microscopy. Over the course of the 16-week degradation study, the samples' pores collapsed. The specimens cured at 120℃ demonstrated the most degradation and became gel-like after 16 weeks. Thermal changes were most evident in the 120℃ and 140℃ cure PGS specimens, as shifts in the melting and recrystallization temperatures occurred. Porous samples cured at all three temperatures displayed a decrease in compressive modulus after 16 weeks. This in vitro study helped to elucidate the effects of porosity and cure temperature on the biodegradation of PGS and will be valuable for the design of future PGS scaffolds.
机译：聚癸二酸甘油酯（PGS）是一种可生物降解且具有生物相容性的弹性体，已被广泛用于生物医学应用中。尽管多孔形式对于组织工程支架而言是常见的，但是为了使细胞向内生长，PGS降解主要是在无孔形式下进行的。本研究的目的是研究三种常用的固化温度：120℃，140℃和165℃下多孔PGS的降解。使用热重分析，差示扫描量热法，傅里叶变换红外光谱，压缩测试和扫描电子显微镜检查了热，化学，机械和形态的变化。在为期16周的降解研究过程中，样品的孔塌陷了。在120℃下固化的样品表现出最大的降解，并在16周后变成凝胶状。随着熔融温度和重结晶温度的变化，在120℃和140℃固化的PGS试样上，热变化最为明显。在所有三个温度下固化的多孔样品在16周后显示出压缩模量的降低。这项体外研究有助于阐明孔隙率和固化温度对PGS生物降解的影响，对于未来PGS支架的设计具有重要价值。

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