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首页> 外文会议>Advancing science, technology, and trade in the age of globalization : A call for every sector of Chinese and global soy industries : Proceedings >GCP (Genistein Combined Polysaccharide): A Soybean Isoflavone Dietary Supplement Fermented by Basidiomycetes With Anticarcinogenic Activities-Their Molecular Mechanism and Chemopreventive Potential
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GCP (Genistein Combined Polysaccharide): A Soybean Isoflavone Dietary Supplement Fermented by Basidiomycetes With Anticarcinogenic Activities-Their Molecular Mechanism and Chemopreventive Potential

机译：GCP（Genistein结合多糖）：担子菌发酵的大豆异黄酮膳食补充剂，具有抗癌活性，其分子机理和化学预防潜力

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Epidemiological as well as experimental studies have revealed that soy isoflavones exert Chemopreventive effects on several types of human cancer. Isoflavones identified in soybeans are mainly glycosides, including genistin, daidzin and glycitin, that are conjugated with glucose. Their active forms are deglycosylated aglycones, such as genistein, daidzein and glycitein. Genistein is a well-known molecule which exerts multiple biological activities. These include inhibition of tyrosine kinases, inactivation of DNA topoisomerase Ⅱ, anti -angiogenesis and cell growth arrest by interfering with signal transduction cascades. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides. Genistein is absorbed in the gut, taken up by the liver and excreted in the bile as its 7-O-beta-glucuronide. The principal metabolites of genistein in the circulation are glucuronide and sulfate conjugates. Conjugated genistein is excreted into urine or bile. Soy isoflavone glycosides are degraded into their aglycone mainly through metabolism by gut microflora. Endo-β-D-glucuronidase (commonly referred to as heparanase) is an extracellular matrix enzyme that degrades heparan sulfate and heparan sulfate proteoglycans, the major components of extracellular matrix and vascular basement membrane. This enzyme is expressed in low level in normal tissues, but is expressed to a higher extent during inflammation, angiogenesis or malignant transformation. These results may be due to differential rates of genistein metabolism in normal and abnormal tissues. Genistein exerts its biological activities when the conjugated genistein is degraded into an aglycone by β-glucuronidase.
机译：流行病学和实验研究表明，大豆异黄酮对几种类型的人类癌症具有化学预防作用。大豆中鉴定出的异黄酮主要是与葡萄糖结合的苷，包括染料木苷，大豆苷和糖苷。它们的活性形式是去糖基化糖苷配基，如染料木黄酮，大豆苷元和糖精蛋白。金雀异黄素是一种众所周知的分子，具有多种生物活性。其中包括酪氨酸激酶的抑制，DNA拓扑异构酶Ⅱ的失活，抗血管生成和通过干扰信号转导级联而阻止细胞生长。大豆异黄酮苷元比其糖苷吸收更快，吸收量更高。金雀异黄素被肠吸收，被肝脏吸收，并以7-O-β-葡糖醛酸苷的形式排入胆汁。金雀异黄素在循环中的主要代谢产物是葡糖醛酸苷和硫酸盐结合物。共轭染料木黄酮被排泄到尿液或胆汁中。大豆异黄酮苷主要通过肠道菌群代谢而降解为糖苷配基。内切-β-D-葡糖醛酸糖苷酶（通常称为乙酰肝素酶）是一种细胞外基质酶，可降解硫酸乙酰肝素和硫酸乙酰肝素蛋白聚糖，这是细胞外基质和血管基底膜的主要成分。该酶在正常组织中低水平表达，但在炎症，血管生成或恶性转化过程中表达较高。这些结果可能是由于正常和异常组织中染料木素的新陈代谢速率不同所致。当结合的染料木黄酮被β-葡萄糖醛酸苷酶降解为糖苷配基时，染料木黄酮发挥其生物学活性。

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