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首页> 外文会议>Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Fluorescence-based method for assessment of blood-brain barrier disruption
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Fluorescence-based method for assessment of blood-brain barrier disruption

机译：基于荧光的血脑屏障破坏评估方法

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摘要

We report on a fluorescence-based optical method for assessment of blood-brain barrier in humans. The technique is based on monitoring of fluorescence light excited in the dye circulating in the brain. Measurements were carried out in healthy volunteers and in patients with disruption of the blood-brain barrier with the use of time-resolved method during inflow and washout of indocyanine green after its intravenous injection. We show large differences in the fluorescence signals - in healthy subjects a fast washout of the dye can be observed whereas in patients the washout is significantly prolonged. We conclude that the monitoring of the fluorescence signals during injection of exogenous optical contrast agent can be used for the assessment of the condition of blood-brain barrier at the bedside. The technique may be of benefit for diagnosis of the patients suffering from damage of the blood-brain barrier and in monitoring of therapies used in such patients.
机译：我们报告了一种基于荧光的光学方法，用于评估人的血脑屏障。该技术基于监视在大脑中循环的染料中激发的荧光。在吲哚菁绿静脉注射后流入和冲洗期间，在健康志愿者和血脑屏障破裂的患者中使用时间分辨方法进行测量。我们在荧光信号上显示出很大的差异-在健康受试者中，可以观察到染料的快速洗脱，而在患者中，洗脱时间明显延长。我们得出结论，在注射外源性光学造影剂期间对荧光信号的监测可用于评估床旁血脑屏障的状况。该技术可能有益于诊断遭受血脑屏障损害的患者并监测用于此类患者的疗法。

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