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首页> 外文会议>Annual Computational Neuroscience Meeting(CNS'02); 20020721-20020725; Chicago,IL; US >Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs
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Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs

机译：突触后反应的变异性非线性地取决于突触输入的数量

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摘要

A conductance-based model for synaptic transmission and postsynaptic integration reveals how postsynaptic responses and their variability depend on the number of synaptic inputs. With increasing number of balanced stochastic excitatory and inhibitory inputs, the postsynaptic responses and their variance first increase and then decrease again. This non-linearity can be attributed to an anti-correlation between the total excitatory and inhibitory currents. The anti-correlation, which occurs even though the conductances of the individual synapses vary independently of each other, is determined by the total synaptic conductance and grows with the number of inputs. As the number of inputs increases, the membrane potential comes increasingly closer to the resting level.
机译：基于电导的突触传递和突触后整合模型揭示了突触后反应及其变异性如何取决于突触输入的数量。随着平衡的随机性兴奋性和抑制性输入的数量增加，突触后反应及其方差首先增加，然后又减少。这种非线性可以归因于总的励磁电流和抑制电流之间的反相关。即使各个突触的电导彼此独立变化，也会发生反相关，该反相关由总的突触电导决定，并随输入数量的增加而增加。随着输入数量的增加，膜电位越来越接近静息水平。

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