THE BASICS OF BIOMOLECULAR TRANSPORT IN NANOCHANNELS: IMPLICATIONS FOR DRUG DELIVERY

机译：纳米通道中生物分子运输的基础：对药物输送的影响

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

In this paper we discuss the fundamentals of electroosmotic flow and biomolecular transport in nanochannels with applications to drug delivery systems. Drug delivery systems transport biomolecules much like natural ion channels, and the flow processes in these two devices are described in terms of a mathematical model. Results of the model, including potential, velocity and concentration are presented for a variety of nanochannel systems. The model is validated for two systems: an electroosmotic pump and a diffusion pump demonstrated by iMEDD, Inc. of Columbus, Ohio. The model is shown to reproduce the experimental data with a high degree of accuracy. In particular, the model reproduces the flux of albumin and glucose through channels as small as seven nanometers.

机译：在本文中，我们讨论了电渗流和纳米通道中生物分子运输的基本原理及其在药物递送系统中的应用。药物输送系统非常像天然离子通道那样输送生物分子，这两个设备中的流动过程是根据数学模型描述的。给出了各种纳米通道系统的模型结果，包括电势，速度和浓度。该模型针对两个系统进行了验证：俄亥俄州哥伦布市的iMEDD，Inc.演示了电渗泵和扩散泵。该模型显示出可以高度精确地重现实验数据。特别地，该模型再现了白蛋白和葡萄糖通过小至7纳米的通道的通量。

著录项

来源
《Annual Conference Nanotech and Biotech Convergence 2004 vol.3; 20040328-30; Cambridge,MA(US)》|2004年|P.259-268|共10页
会议地点 CambridgeMA(US)
作者
A. Terry Conlisk; Andrew Kebbel; Ankan Kumar;
展开▼
作者单位

Mechanical Engineering Department of Mechanical Engineering Ohio State University Columbus, OH 43210;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
关键词

相似文献

外文文献
中文文献
专利

1. Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery [J] . Pearson Ryan M., Juettner Vanessa V., Hong Seungpyo Frontiers in Chemistry . 2014,第2008期

机译：纳米粒子上的生物分子电晕：近期文献综述及其对靶向药物递送的影响
2. pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. [J] . Neuhoff S, Ungell AL, Zamora I, Pharmaceutical research . 2003,第8期

机译：pH依赖性弱碱性药物跨Caco-2单层的双向运输：对药物相互作用的影响。
3. Ordered mesoporous magnesium silicate with uniform nanochannels as a drug delivery system: The effect of calcination temperature on drug delivery rate [J] . Bigham Ashkan, Hassanzadeh-Tabrizi S. A., Rafienia Mohammad, CERAMICS INTERNATIONAL . 2016,第15期

机译：具有均匀纳米通道的有序介孔硅酸镁作为药物输送系统：煅烧温度对药物输送速率的影响
4. THE BASICS OF BIOMOLECULAR TRANSPORT IN NANOCHANNELS: IMPLICATIONS FOR DRUG DELIVERY [C] . A. Terry Conlisk, Andrew Kebbel, Ankan Kumar Annual Conference on Nanotech and Biotech Convergence . 2004

机译：纳米南尔斯生物分子运输的基础知识：对药物递送的影响
5. Roles of drug basicity, melanin binding, and cellular transport in drug incorporation into hair. [D] . Borges, Chad Randolph. 2001

机译：药物碱性，黑色素结合和细胞转运在药物掺入头发中的作用。
6. Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery [O] . Ryan M. Pearson, Vanessa V. Juettner, Seungpyo Hong 2014

机译：纳米粒子上的生物分子电晕：近期文献综述及其对靶向药物递送的影响
7. Biomolecular Corona on Nanoparticles: A Survey of Recent Literature and its Implications in Targeted Drug Delivery [O] . Ryan Matthew Pearson, Vanessa eJuettner, Seungpyo eHong 2014

机译：纳米粒子上的生物分子电晕：近期文献综述及其在靶向给药中的意义

THE BASICS OF BIOMOLECULAR TRANSPORT IN NANOCHANNELS: IMPLICATIONS FOR DRUG DELIVERY

摘要

著录项

相似文献

相关主题

期刊订阅