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Evaluation of Antitumor Activity of Doxorubicin-Loaded Triblock Micelles in 3-D Multicellular Spheroids and Tumor-bearing Mouse Models for Cancer Chemotherapy

机译：阿霉素三嵌段胶束在3-D多细胞球体和荷瘤小鼠模型中的抗癌活性的癌症化疗的评价。

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Triblock copolymers based on poly (ethylene oxide)-poly [(R)-3-hydroxybutyrate] - poly (ethylene oxide) applied as a doxorubicin (DOX) delivery micelle system for cancer therapy. The intracellular uptake of DOX to DOX-resistant cells and penetration of DOX into 3D-multicellular spheroids (MCS) was enhanced when it was delivered via micelle system. We demonstrated that administration of DOX-loaded micelles to SiHa xenograft mice led to abrogation of tumor development.

机译：基于聚（环氧乙烷）-聚[（R）-3-羟基丁酸酯]-聚环氧乙烷的三嵌段共聚物，用作阿霉素（DOX）传递胶束系统，用于癌症治疗。当通过胶束系统递送时，DOX对抗DOX的细胞的细胞内摄取以及DOX渗透到3D多细胞球体（MCS）中的能力得到增强。我们证明了向SiHa异种移植小鼠施用DOX加载的胶束导致肿瘤发展的废除。

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《Annual meeting exposition of the Controlled Release Society》|2010年|p.1209-1210|共2页
会议地点 Portland OR(US)
作者
T.H.Kim; C. Mount; T. Goodman; W. Gombotz; S. Pun;
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Department of Bioengineering University of Washington Seattle WA 98195 USA;

Omeros Corporation 1420 Fifth Avenue Suite 2600 Seattle WA 98101 USA;

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1. The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. [J] . Kim TH, Mount CW, Gombotz WR, Biomaterials . 2010,第28期

机译：使用穿透肿瘤的三嵌段聚合物胶束在小鼠异种移植模型中将阿霉素递送至3-D多细胞球体和肿瘤。
2. Core-Cross-Linking Accelerates Antitumor Activities of Paclitaxel-Conjugate Micelles to Prostate Multicellular Tumor Spheroids: A Comparison of 2D and 3D Models [J] . Du Alice W., Lu Hongxu, Stenzel Martina H. Biomacromolecules . 2015,第5期

机译：核心交叉链接加速紫杉醇共轭胶束对前列腺多细胞肿瘤球体的抗肿瘤活性：2D和3D模型的比较。
3. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG-PE micelles in ovarian cancer cell spheroid model [J] . Perche F., Patel N.R., Torchilin V.P. Journal of Controlled Release: Official Journal of the Controlled Release Society . 2012,第1期

机译：靶向阿霉素的PEG-PE胶束在卵巢癌细胞球体模型中的蓄积和毒性
4. Graft / triblock copolymer reduction-sensitive micelles with different hydrophobic chain molecular weight for cancer chemotherapy [C] . Yong Sun, Yihang Huang, Taiming Yuan, World biomaterials congress . 2012

机译：疏水链分子量不同的接枝/三嵌段共聚物还原敏感胶束用于癌症化疗
5. Synthesis and Biological Evaluation of 2-N-bis-(benzoyl)amino- 1,4-naphthoquinone, 2-arylnaphtho[2,3-d]oxazole-4,9-dione and 2-aryl-4-phenyliminonaphtho[2,3-d]oxazol-9-one Analogs as Potential Chemotherapy for Prostate Cancer. [D] . Brandy, Yakini S.A. 2012

机译：2-N-双-（苯甲酰基）氨基-1,4-萘醌，2-芳基萘[2,3-d]恶唑-4,9-二酮和2-芳基-4-苯基亚氨基萘[2，]的合成及生物评价3-d]恶唑-9-类似物作为前列腺癌的潜在化学疗法。
6. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG-PE micelles in ovarian cancer cell spheroid model [O] . Federico Perche, Vladimir P. Torchilin -1

机译：卵巢癌细胞球状模型中抗体靶向多柔比星的PEG-PE胶束的累积和毒性
7. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG–PE micelles in ovarian cancer cell spheroid model [O] . Federico Perche, Niravkumar R. Patel, Vladimir P. Torchilin 2012

机译：卵巢癌细胞球状模型中抗体靶向多柔比星的PEG-PE胶束的累积和毒性

Evaluation of Antitumor Activity of Doxorubicin-Loaded Triblock Micelles in 3-D Multicellular Spheroids and Tumor-bearing Mouse Models for Cancer Chemotherapy

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