Indomethacin-Loaded Amphiphilic Poly-N-Vinylpyrrolidone Nanoparticles: Preparation, Properties and Drug Release Behavior

机译：吲哚美辛负载的两亲性聚N-乙烯基吡咯烷酮纳米颗粒：制备，性质和药物释放行为

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Amphiphilic poly-N-vinylpyrrolidone derivatives with different molecular weight of hydrophilic poly-N-vinylpyrrolidone fragment and one terminal hydrophobic n-alkyl fragment of different length were synthesized. Fluorescence analysis showed that prepared polymers can self-associate to form polymeric nanoparticles in aqueous media. Indomethacin was encapsulated during formation of nanoparticles and its in vitro release properties were investigated. Drug loading efficiency was up to 60 % and loaded indomethacin was slowly and steadily released into the medium over the period of 12 days.

机译：合成了具有不同分子量的亲水性聚N-乙烯基吡咯烷酮片段和一个不同长度的末端疏水性正烷基片段的两亲性聚N-乙烯基吡咯烷酮衍生物。荧光分析表明，制备的聚合物可以在水介质中自缔合形成聚合物纳米颗粒。消炎痛在纳米粒子形成过程中被封装，并对其体外释放性能进行了研究。载药效率高达60％，并在12天的时间内将负载的吲哚美辛缓慢稳定地释放到培养基中。

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《Annual meeting exposition of the Controlled Release Society》|2010年|p.1620-1621|共2页
会议地点 Portland OR(US)
作者
Andrey N. Kuskov; Anastasiya V. Goryachaya; Anna A. Voskresenskaya; Mikhail I. Shtilman;
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D.I. Mendeleyev University of Chemical Technology of Russia Moscow 125047 Russia;

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1. Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: Characterization and in vitro controlled release of indomethacin [J] . KuskovA. N., VoskresenskayaA. A., GoryachayaA. V., International journal of molecular medicine . 2010,第1期

机译：两亲性聚-N-乙烯基吡咯烷酮纳米颗粒作为非甾体类抗炎药的载体：消炎痛的表征和体外控制释放
2. Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal anti-inflammatory drugs: characterization and in vitro controlled release of indomethacin. [J] . Kuskov AN, Voskresenskaya AA, Goryachaya AV, International journal of molecular medicine . 2010,第1期

机译：两亲性聚-N-乙烯基吡咯烷酮纳米颗粒作为非甾体抗炎药的载体：吲哚美辛的表征和体外控制释放。
3. Preparation and drug release behaviors of nimodipine-loaded poly(caprolactone)-poly(ethylene oxide)-polylactide amphiphilic copolymer nanoparticles. [J] . Hu Y, Jiang X, Ding Y, Biomaterials . 2003,第13期

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Indomethacin-Loaded Amphiphilic Poly-N-Vinylpyrrolidone Nanoparticles: Preparation, Properties and Drug Release Behavior

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