首页>
外国专利>
PREPARATION AND APPLICATION OF AMPHIPHILIC DRUG-DRUG NANOPARTICLE FOR REVERSING PLATINUM-BASED ANTICANCER DRUG RESISTANCE IN CANCER THERAPY
PREPARATION AND APPLICATION OF AMPHIPHILIC DRUG-DRUG NANOPARTICLE FOR REVERSING PLATINUM-BASED ANTICANCER DRUG RESISTANCE IN CANCER THERAPY
展开▼
机译:逆转铂基抗癌药耐药性的两用药物纳米颗粒的制备及应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
An amphiphilic drug-drug nanoparticle for reversing platinum-based anticancer drug resistance in cancer therapy, which is formed through coordination of a histone deacetylase inhibitor with a platinum-based antitumor agent and self-assembly in water. After entering tumor cells, the amphiphilic drug-drug nanoparticle can hydrolyze to release two drug agents. The amphiphilic complex can self-assemble into nanoparticles in water without any carriers, and the complex can realize drug delivery by itself. At the meantime, the amphiphilic drug-drug nanoparticle can effectively enter tumor cells, reduce the blocking effect of sulfur-containing ligands in blood on cisplatin, and decrease the toxic and side effects towards normal cells. It can also be hydrolyzed to release the histone deacetylase inhibitor and platinum-based antitumor active agents, thereby achieving the synergistic effect for reversing platinum-based drug resistance in cancer therapy and the purpose of cancer treatment.
展开▼