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首页> 外文会议>Bioceramics 23 >Development and Mechanical Characterization of a Collagen/Hydroxyapatite Bilayered Scaffold for Ostechondral Defect Replacement
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Development and Mechanical Characterization of a Collagen/Hydroxyapatite Bilayered Scaffold for Ostechondral Defect Replacement

机译：胶原/羟基磷灰石双层支架用于骨软骨缺损置换术的开发和力学表征

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In this work a novel three-dimensional ostechondral substitute is proposed that is made of an inorganic/organic hybrid material, namely collagen/hydroxyapatite. The two components of the substitute have been characterized separately. The inorganic part, a hydroxyapatite scaffold, was fabricated by a polymer sponge templating method using a reactive sub-micron powder synthesized in our laboratory by hydroxide precipitation sol-gel route. The organic part, a collagen scaffold, was fabricated by a freeze-dying technique varying design parameters. Both the parts were analysed by scanning electron microscopy and their mechanical properties assessed by compression tests. The hydroxyapatite scaffold showed a high and highly interconnected porosity and a mechanical strength equal to 0.55 MPa, higher than those reported in literature. The collagen scaffolds were seeded by chondrocytes, processed for histology analysis and tested in compression. The biological tests proved the ability of the scaffolds to be positively populated by chondrocytes and the mechanical analysis showed that the mechanical strength of the scaffolds significantly increased after 3 weeks of culture.
机译：在这项工作中，提出了一种新型的三维骨替代物，它是由无机/有机杂化材料制成的，即胶原蛋白/羟基磷灰石。替代品的两个成分已分别进行了表征。无机部分，羟基磷灰石支架，是通过聚合物海绵模板法，使用在我们实验室中通过氢氧化物沉淀溶胶-凝胶法合成的反应性亚微米粉末制成的。通过冷冻染色技术改变设计参数来制造有机部分，即胶原蛋白支架。通过扫描电子显微镜分析两个部件，并通过压缩测试评估它们的机械性能。羟基磷灰石支架显示出高且高度相关的孔隙率，机械强度等于0.55 MPa，高于文献报道的那些。胶原支架由软骨细胞播种，进行组织学分析并进行压缩测试。生物学测试证明了支架能够被软骨细胞阳性填充，并且力学分析表明，在培养3周后支架的机械强度显着提高。

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