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首页> 外文会议>Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on >Differential Expression and Regulation of Angiopoietin-1 in Mouse Ovary during Sexual Maturation and Luteal Development
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Differential Expression and Regulation of Angiopoietin-1 in Mouse Ovary during Sexual Maturation and Luteal Development

机译：性成熟和黄体发育过程中小鼠卵巢中血管生成素-1的差异表达和调控

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Angiogenesis, the development of new blood vessels from preexistent vasculature, is recognized to play important roles during follicular development and atresia, ovulation, and the subsequent development and regression of corpus luteum. However, as an important angiogenic factor, the effect of Angiopoietin-1 (Ang-1) in the process of mouse ovary angiogenesis is still not defined in detail so far. The aim of this study was to examine the expression and regulation of Ang-1 in mouse ovary during sexual maturation, follicular development induced by eCG, ovulation induced by hCG and corpus luteum formation and regression by reverse transcription polymerase chain reaction (RT-PCR). The results showed that Ang-1 mRNA expression level was lower on days 10 and 20 after birth, but it was sharply increased on day 25 after birth, while generally decreased. Ang-1 mRNA expression reached the peak level at 48 hours after injection of eCG. At 3, 5 and 9 hours after injection of hCG, Ang-1 mRNA expression decreased, while at 0.5 and 7 hours after injection of hCG, Ang-1 mRNA expression level was higher. Ang-1 mRNA was expressed on days 1-15 after injection of hCG, and Ang-1 expression increased gradually on days 5-15 after injection of hCG, while Ang-1 expression level reached maximum on day 15 after injection of hCG. These results suggest that Ang-1 may play a role during the process of mouse follicular development, ovulation and corpus luteum formation and regression.
机译：血管生成是从先前存在的脉管系统发育而来的新血管的发育，在卵泡发育和闭锁，排卵以及随后的黄体发育和消退中起着重要作用。然而，作为重要的血管生成因子，Angiopoietin-1（Ang-1）在小鼠卵巢血管生成过程中的作用至今仍未得到详细定义。这项研究的目的是研究性成熟，eCG诱导的卵泡发育，hCG诱导的排卵和黄体形成以及通过逆转录聚合酶链反应（RT-PCR）退化期间Ang-1在小鼠卵巢中的表达和调控。 。结果表明，Ang-1 mRNA的表达水平在出生后第10和20天较低，但在出生后第25天急剧上升，但总体上下降。注射eCG后48小时，Ang-1 mRNA表达达到峰值。注射hCG后3、5和9小时，Ang-1 mRNA表达下降，而注射hCG后0.5和7小时，Ang-1 mRNA表达水平更高。注射hCG后第1-15天Ang-1 mRNA表达，注射hCG后第5-15天Ang-1表达逐渐增加，而注射hCG后第15天Ang-1表达达到最高。这些结果表明，Ang-1可能在小鼠卵泡发育，排卵，黄体形成和退化过程中起作用。

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