Adaptive Optical Microscope for Brain Imaging in vivo

机译：用于体内脑成像的自适应光学显微镜

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摘要

The optical heterogeneity of biological tissue imposes a major limitation to acquire detailed structural and functional information deep in the biological specimens using conventional microscopes. To restore optimal imaging performance, we developed an adaptive optical microscope based on direct wavefront sensing technique. This microscope can reliably measure and correct biological samples induced aberration. We demonstrated its performance and application in structural and functional brain imaging in various animal models, including fruit fly, zebrafish and mouse.

机译：生物组织的光学异质性对使用常规显微镜在生物样本的深处获取详细的结构和功能信息施加了主要限制。为了恢复最佳的成像性能，我们开发了一种基于直接波前传感技术的自适应光学显微镜。该显微镜可以可靠地测量和校正生物样品引起的像差。我们在各种动物模型（包括果蝇，斑马鱼和小鼠）中证明了其在结构和功能性大脑成像中的性能和应用。

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来源
《Biomedical imaging and sensing conference》|2017年|102510h.1-102510h.2|共2页
会议地点 Yokohama(JP)
作者
Kai Wang;
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作者单位

Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.,University of Chinese Academy of Sciences, Beijing 100049, China;

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会议组织
原文格式 PDF
正文语种 eng
中图分类
关键词
Microscopy; Biomedical Optical Imaging; Adaptive Optics;

机译：显微镜；生物医学光学成像；自适应光学;

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1. Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging [J] . Wolak Daniel J., Pizzo Michelle E., Thorne Robert G. Journal of Controlled Release: Official Journal of the Controlled Release Society . 2015,第Null期

机译：使用体内整合光学成像和离体荧光成像探测脑中抗体的细胞外扩散
2. In Vivo and Online Optical Ascorbic Acid Monitoring in Living Rat Brains Using a Brightfield Microscope-Based Online Detection Platform [J] . Wang Chao, Bi Xinyu, Zhao Xu, ACS Sustainable Chemistry & Engineering . 2019,第4期

机译：在使用基于明场显微镜的在线检测平台的生活大鼠脑中的体内和在线光学抗坏血酸监测
3. Aberration correction during real time in vivo imaging of bone marrow with sensorless adaptive optics confocal microscope [J] . Zhibin Wang, Dan Wei, Ling Wei, Journal of biomedical optics . 2014,第8期

机译：无传感器自适应光学共聚焦显微镜在骨髓实时体内成像中的像差校正
4. Adaptive Optical Microscope for Brain Imaging in vivo [C] . Kai Wang Biomedical imaging and sensing conference . 2017

机译：用于体内脑成像的自适应光学显微镜
5. Multidimensional deconvolution of optical microscope and ultrasound imaging using adaptive least-mean-square (LMS) inverse filtering [D] . Sapia, Mark Angelo. 2000

机译：使用自适应最小均方（LMS）逆滤波的光学显微镜和超声成像多维反卷积
6. Adaptive optical versus spherical aberration corrections for in vivo brain imaging [O] . Raphaël Turcotte, Yajie Liang, Na Ji 2017

机译：体内大脑成像的自适应光学与球差校正
7. Adaptive Scanning Optical Microscope (ASOM): A multidisciplinary optical microscope design for large field of view and high resolution imaging [O] . Potsaid, B, Bellouard, YJ Yves, Wen, JT 2005

机译：自适应扫描光学显微镜（ASOM）：多学科光学显微镜设计，适用于大视野和高分辨率成像

Adaptive Optical Microscope for Brain Imaging in vivo

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