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首页> 外文会议>Biomedical Science amp; Engineering Conference, 2009. BSEC 2009 >“Translating novel engineering concepts into biomedical research programs and clinical medicine”
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“Translating novel engineering concepts into biomedical research programs and clinical medicine”

机译：“将新颖的工程概念转化为生物医学研究计划和临床医学”

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Translational research embodies the concept of moving the application of novel hypotheses, technologies, and methodologies from the bench to the bedside, bedside to community, and community to the health policy arena to effect beneficial change in patient care, health care costs and outcomes, and to improve the public health. Successful translational research in medicine and biology seeks to leverage the innovation that occurs at the interface between disparate scientific disciplines and translate it into new technologies for novel clinical applications and practice. Science occurring at the interface between disciplines brings researchers together to create new scientific approaches to traditional problems. Not uncommonly, it is the technology that drives the process, often in a non-linear fashion and in unforeseen directions. Successful collaborations may hinge upon letting go of one's field of interest to pursue innovation in another. Success in this area is often achieved by building and funding diverse research teams and letting them innovate freely. In my presentation, I will give the audience an overview of my experiences in the development, funding, and challenges of building a diverse portfolio of translational research programs addressing a broad spectrum of medical and public health problems. These include: tissue engineering and genomics approaches to understanding and modulating aging and injury responses in the eye, telemedicine, the application of novel image analysis methods to the development of web-based, automated, population screening and management of diabetic retinopathy in underserved populations and for national clinical trials and nanotechnology applying novel biomaterials, and carbon nanofiber electrochemical sensors, to improve clinical medicine and surgery through novel ocular surgical instrument designs and nanofabrication techniques. These programs have earned the support of diverse governmental and non-governmental funding agencies in-ncluding the National Eye Institute, the United States Army, Oak Ridge National Laboratory, HRSA, the pharmaceutical industry, and several private philanthropies. Finally, I will touch upon key features of successful translational teams including mentorship, identification of continuing resources to sustain progress and grantsmanship.
机译：转化研究体现了以下概念：将新颖的假设，技术和方法的应用从工作台转移到床边，从床边转移到社区，再到社区再到卫生政策领域，以实现患者护理，卫生保健成本和结果的有益变化，以及改善公众健康。成功的医学和生物学转化研究试图利用在不同科学学科之间的交界处发生的创新，并将其转化为用于新的临床应用和实践的新技术。学科之间交界处发生的科学使研究人员聚集在一起，为传统问题创造了新的科学方法。通常，这种技术通常以非线性方式和无法预料的方向驱动过程。成功的合作可能取决于放任自己感兴趣的领域去追求另一个领域的创新。在这一领域的成功通常是通过建立和资助各种研究团队并让他们自由创新来实现的。在我的演讲中，我将向观众概述我在开发，解决各种医学和公共卫生问题的多样化翻译研究计划组合方面的发展，资金和挑战方面的经验。其中包括：组织工程学和基因组学方法，以了解和调节眼部衰老和损伤反应；远程医疗；将新颖的图像分析方法应用于在服务不足的人群中开发基于网络的，自动化的，人群筛查和糖尿病性视网膜病变的管理方法，以及适用于采用新型生物材料和碳纳米纤维电化学传感器的国家临床试验和纳米技术，通过新型眼外科器械设计和纳米加工技术来改善临床医学和外科手术。这些计划获得了各种政府和非政府资助机构的支持，其中包括国家眼科研究所，美国陆军，橡树岭国家实验室，HRSA，制药业和一些私人慈善机构。最后，我将介绍成功的翻译团队的关键特征，包括指导，确定持续进步的持续资源和奖学金。

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