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首页> 外文会议>Biomedical vibrational spectroscopy 2016: Advances in research and industry >Towards optical fibre based Raman spectroscopy for the detection of surgical site infection
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Towards optical fibre based Raman spectroscopy for the detection of surgical site infection

机译：迈向基于光纤的拉曼光谱仪以检测手术部位感染

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Surgical site infections (SSIs) are common post-surgical complications that remain significant clinical problems, as they are associated with substantial mortality and morbidity. As such, there is significant interest in the development of minimally invasive techniques that permit early detection of SSIs. To this end, we are applying a compact, clinically deployable Raman spectrometer coupled to an optical fibre probe to the study of bacteria, with the long term goal of using Raman spectroscopy to detect infection in vivo. Our system comprises a 785 nm laser diode for excitation and a commercial (Ocean Optics, Inc.) Raman spectrometer for detection. Here we discuss the design, optimisation and validation of this system, and describe our first experiences interrogating bacterial cells (Escherichia coli) in vitro.
机译：手术部位感染（SSI）是常见的手术后并发症，仍然存在重大的临床问题，因为它们与大量的死亡率和发病率相关。因此，对允许早期检测SSI的微创技术的发展引起了极大的兴趣。为此，我们正在将紧凑的，可临床部署的拉曼光谱仪与光纤探头耦合用于细菌研究，其长期目标是使用拉曼光谱在体内检测感染。我们的系统包括用于激发的785 nm激光二极管和用于检测的商用（Ocean Optics，Inc.）拉曼光谱仪。在这里，我们讨论该系统的设计，优化和验证，并描述我们在体外询问细菌细胞（大肠杆菌）的最初经验。

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