Investigation of ssDNA molecule using Clustered Atomistic Method and its Application to the dsDNA Analysis

机译：聚类原子法研究ssDNA分子及其在dsDNA分析中的应用

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A novel single-stranded DNA (ssDNA) model based on the clustered atomistic method is conducted to simulate the meso-mechanics of ssDNA molecule. Through the validation of the single molecular experiment, the proposed ssDNA model could represent the ssDNA molecule in different counter length, and the mechanical characteristic of the ssDNA molecule in external tensile loading could be elucidated. Furthermore, the characteristic of the validated ssDNA model is adapted in the double-stranded DNA (dsDNA) model. The simulation result of the dsDNA model under external loading reveals mechanical behavior of the dsDNA B-S structural transition. Good agreement is achieved between the numerical simulation and single molecular manipulation experimental result, and the mechanical behavior of stretching nicked dsDNA could be revealed.

机译：建立了基于聚类原子方法的新型单链DNA（ssDNA）模型，以模拟ssDNA分子的细观力学。通过单分子实验的验证，所提出的ssDNA模型可以代表不同长度的ssDNA分子，并阐明了ssDNA分子在外部拉伸载荷下的力学特性。此外，已验证的ssDNA模型的特征适用于双链DNA（dsDNA）模型。 dsDNA模型在外部载荷下的仿真结果揭示了dsDNA B-S结构转变的力学行为。数值模拟与单分子操作实验结果之间取得了良好的一致性，并且可以揭示有切口的dsDNA的力学行为。

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来源
《BioMEMS and Nanotechnology II; Progress in Biomedical Optics and Imaging; vol.6 no.40》|2005年|P.603605.1-603605.8|共8页
会议地点 Brisbane(AU)
作者
Cheng-Nan Han; Cadmus Yuan; Kuo-Ning Chiang;
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作者单位

Advanced Microsystem Packaging Nano-Mechanics Research Lab Dept. of Power Mechanical Engineering National Tsing Hua University HsinChu, Taiwan 300;

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原文格式 PDF
正文语种 eng
中图分类光、激光生物医学;
关键词
single molecular simulation; DNA; finite element method; equivalent theory; meso-mechanics;

机译：单分子模拟DNA有限元法等效理论细观力学;

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Investigation of ssDNA molecule using Clustered Atomistic Method and its Application to the dsDNA Analysis

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