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首页> 外文会议>BioMEMS and Nanotechnology II; Progress in Biomedical Optics and Imaging; vol.6 no.40 >Enhanced Electrokinetic Manipulation and Impedance Sensing using FPGA Digital Signal Processing
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Enhanced Electrokinetic Manipulation and Impedance Sensing using FPGA Digital Signal Processing

机译：使用FPGA数字信号处理增强的电动操纵和阻抗感测

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摘要

Electrokinetic manipulation of microscopic biological particles, such as bacteria and other cells, is useful in the technology of lab-on-a-chip devices and micro-total-analysis systems (μTAS). In electrokinetic manipulation, non-uniform electric fields are used to exploit the dielectric properties of suspended biological microparticles, to induce forces and torques on the particles. The electric fields are produced by planar electrode arrays patterned on electrically-insulating substrates. Biological microparticles are dielectrically-heterogeneous structures. Each different type of biological cell has a distinct dielectric frequency response signature. This dielectric distinction allows specificity when manipulating biological microparticles using electrokinetics. Electrokinetic microbiological particle manipulation has numerous potential applications in biotechnology, such as the separation and study of cancerous cells, determining the viability of cells, as well as enabling more automation and parallelization in microbiological research and pathology. This paper presents microfabricated devices for the manipulation of biological microparticles using electrokinetics. Methods of impedance sensing for determining microparticle concentration and type are also discussed. This paper also presents methods of using digital signal processing systems to enhance the manipulation and sensing of the microbiological particles. A Field-Programmable Gate Array (FPGA) based system is demonstrated which is used to digitally synthesize signals for electrokinetic actuation, and to process signals for impedance sensing.
机译：微观生物颗粒（例如细菌和其他细胞）的电动操纵可用于芯片实验室设备和总分析系统（μTAS）的技术中。在电动操纵中，非均匀电场用于开发悬浮的生物微粒的介电性能，以在微粒上感应力和扭矩。电场由在电绝缘基板上构图的平面电极阵列产生。生物微粒是介电异构的结构。每种不同类型的生物细胞都有不同的介电频率响应特征。当使用电动学操作生物微粒时，这种介电特性可以实现特异性。电动微生物粒子操纵在生物技术中具有许多潜在应用，例如癌细胞的分离和研究，确定细胞的活力以及在微生物研究和病理学中实现更多自动化和并行化。本文介绍了利用电动学来操纵生物微粒的微细加工设备。还讨论了用于确定微粒浓度和类型的阻抗感测方法。本文还介绍了使用数字信号处理系统来增强对微生物颗粒的操纵和感测的方法。演示了一种基于现场可编程门阵列（FPGA）的系统，该系统用于数字合成用于电动促动的信号，并处理用于阻抗感测的信号。

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