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Possible role of laser phototherapy in laser immunotherapy

机译:激光光疗在激光免疫疗法中的可能作用

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Laser immunotherapy is a promising cancer treatment method that induces antitumor immunity and appears to be effective both locally and systemically. In this context, an important factor is the overall state of the immune system, both locally and systemically. The success of any immunotherapy treatment depends on the balance between the local immunosuppressive forces induced by the tumor and the immune response of the host organism. Factors that influence this balance include heat-shock proteins (for example HSP70), transforming growth factor β (TGF-β), tumor necrosis factor a (TNF-α), interleukins, and more.rnLaser phototherapy, which is based on non-thermal photobiological processes, has been shown to modulate the body's own immune response, both locally and systemically, with a strong influence on for example cytokine production and heat-shock protein synthesis. Laser phototherapy may therefore be an important component in the overall efficacy of laser immunotherapy, and may tip the balance between the immunosuppressive and immunostimulatory forces in favor of immunostimulation.
机译:激光免疫疗法是一种有前途的癌症治疗方法,可诱导抗肿瘤免疫力,并且在局部和全身均有效。在这种情况下,重要的因素是局部和全身免疫系统的整体状态。任何免疫疗法的成功取决于肿瘤引起的局部免疫抑制力与宿主生物体免疫反应之间的平衡。影响这种平衡的因素包括热休克蛋白(例如HSP70),转化生长因子β(TGF-β),肿瘤坏死因子a(TNF-α),白介素等。热光生物学过程已显示出可以局部和全身调节人体自身的免疫反应,并对例如细胞因子的产生和热激蛋白的合成产生强烈影响。因此,激光光疗可能是激光免疫疗法整体功效的重要组成部分,并可能使免疫抑制力和免疫刺激力之间的平衡趋于有利于免疫刺激。

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