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Mechanistic studies of systemic immune responses induced by laser-nanotechnology

机译：激光纳米技术诱导的全身免疫反应的机理研究

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摘要

With the help of the specific absorption spectrum of carbon nanotubes, we achieved selective photothermal tumor cell destruction, particularly using a near-infrared laser to reduce potential damage to untargeted tissues. Combined with immunological stimulation, using a novel adjuvant, we also observed the anti-tumor immune responses when treating animal tumors using the laser-nano treatment. In fact, the local application of laser-nano-immunotherapy appeared to result in a systemic curative effect. In our mechanistic study, we found that the laser-nano-immuno treatment can activate antigen-presenting cells, such as dendritic cells (DCs). More importantly, the uptake and presentation of antigens by these antigen presenting cells were significantly enhanced, as shown by the strong binding of tumor cells and DCs as well as the proliferation of T cells caused by the DCs after the DCs had been incubated with laser-nano-immuno treated tumors. These cellular observations provide evidence that a systemic anti-tumor immune response was induced by the combination of laser and nanotechnology.
机译：借助碳纳米管的特定吸收光谱，我们实现了选择性的光热肿瘤细胞破坏，特别是使用近红外激光来减少对未靶向组织的潜在损害。结合免疫刺激，使用新型佐剂，我们还观察到了使用激光纳米治疗动物肿瘤时的抗肿瘤免疫反应。实际上，激光纳米免疫疗法的局部应用似乎导致全身疗效。在我们的机制研究中，我们发现激光纳米免疫处理可以激活抗原呈递细胞，例如树突状细胞（DC）。更重要的是，这些抗原呈递细胞对抗原的吸收和呈递显着增强，如肿瘤细胞和DC的强结合以及DC与激光孵育后DC引起的T细胞增殖所表明的那样。纳米免疫治疗的肿瘤。这些细胞学观察提供了证据，表明激光和纳米技术的结合可诱导全身性抗肿瘤免疫反应。

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  • 来源
    《Biophotonics and immune responses IX》|2014年|89440U.1-89440U.6|共6页
  • 会议地点 San Francisco CA(US)
  • 作者

    Wei R. Chen; Feifan Zhou; Brock Henderson; Bailey Vasquez; Hong Liu; Tomas Hode; Robert E. Nordquist;

  • 作者单位

    Department of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma, 73034, USA;

    College of Biophotonics, MOE Key Laboratory of Laser Life Science Institute of Laser Life Science, South China Normal University, Guangzhou, China, 510631;

    Department of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma, 73034, USA;

    Department of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma, 73034, USA;

    Center for Bioengineering and School of Electrical and Computer Engineering University of Oklahoma, 202 W Boyd Rm 219, Norman, OK 73019, USA;

    Immunophotonics Inc., 4041 Forest Park Avenue St. Louis, MO 63108, USA;

    Immunophotonics Inc., 4041 Forest Park Avenue St. Louis, MO 63108, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Dendritic cells; T cell infiltration; nanotechnology; near-infrared laser; cancer treatment; immune responses;

    机译：树突状细胞； T细胞浸润；纳米技术近红外激光癌症治疗；免疫反应;

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